氯喹抗肿瘤作用及研究进展  

Efficacy of Chloroquine in Cancer Therapy

作　　者：李倩[1] 袁冬梅[1] 宋勇[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院呼吸内科,在读研究生南京210002

出　　处：《医学综述》2016年第13期2541-2543,共3页Medical Recapitulate

基　　金：国家自然科学基金(81302032)

摘　　要：氯喹作为传统的老药,不仅用于抗疟疾治疗,还用于类风湿关节炎、红斑狼疮等疾病的治疗。近年发现氯喹还具有抗肿瘤作用,并在克服肿瘤耐药方面发挥重要作用。氯喹不仅通过抑制肿瘤的自噬增加放化疗的敏感性,还可抑制腺苷三磷酸结合体家族蛋白,减少抗肿瘤药物的排出;另外,氯喹还可通过影响DNA分子的稳定性、促进肿瘤血管正常化,同时提高蛋白酶体抑制剂效应、促进肿瘤免疫,进而达到抗肿瘤的作用。Chloroqnine as an old drug, is widely used as an anti-malarial agent and a useful agent for the treatment of rheumatoid arthritis and lupus erythematosus. In recent years, chlaroqnine has been studied for its potential as an enhancing agent in cancer therapies and plays a key role in reversing drug resistance. Chloroquine＇s ability to block autophagy makes it as a potential chemotherapy and radiotherapy sensitizer. Besides,it can also inhibit ATP Binding Cassette family protein to decrease the discharge of anti-tumor drugs ;it can also stabilize DNA,induce tumor vessel normalization,improve the effects of proteasome inhibitom and promote antitumor immunity,thus playing the anti-tumor role.

关 键 词：氯喹 肿瘤耐药 抗肿瘤治疗 抑制自噬 

分 类 号：R730[医药卫生—肿瘤]