老年消化性溃疡复发相关因素分析  

Analysis of correlative factors in peptic ulcer recurrence in the elderly

作　　者：顾廷[1] 黄一沁[1] 于晓峰[1] 季大年[1] 项平[1] 

机构地区：[1]复旦大学附属华东医院消化内科,上海200040

出　　处：《中华消化杂志》2016年第6期388-390,共3页Chinese Journal of Digestion

摘　　要：目的：分析老年消化性溃疡患者复发的相关因素。方法选择2009年1月至12月经内镜检查发现的年龄≥60岁的消化性溃疡患者169例，分析其治疗和药物的使用情况，以及随访3年治疗和复发情况的相关资料。采用 Mann-Whitney 秩和检验和 Logistic 回归分析进行相关影响因素分析。结果对可能影响老年消化性溃疡复发的因素经单因素分析筛选，发现溃疡大小、溃疡部位、联合使用其他损伤胃黏膜药物、吸烟情况和随访期末 H ．pylo狉i 感染状态与溃疡复发有关（P 均＜0.01）。校正年龄、性别后，进行 Logistic 多因素回归分析，发现吸烟情况（OR ＝1.788，P ＝0.001）、联合使用其他损伤胃黏膜药物（OR＝6.202，P ＝0.015）、溃疡大小（OR＝2.697，P ＝0.032）和随访期末的 H ．pylo狉i 感染情况（OR＝43.784，P ＝0.007）与老年消化性溃疡复发有关。结论吸烟情况、联合用药、溃疡大小和随访期末的 H ．pylo狉i 感染情况对老年消化性溃疡复发有影响。Objective To analyze the correlative factors of peptic ulcer recurrence in the elderly. Methods From January to December 2009,169 elderly patients （≥ 60 years old）with peptic ulcer delected by edoscopy were enrolled,whose treatment and usage of medication were analyzed.Data of treatment and recurrence in 3-year follow-up were recorded.Mann-Whitney rank sum test and Logistic regression analysis were performed to analyze the correlated factors.Results The potential risk factors associated with recurrence of peptic ulcer in the elderly were screened and analyzed by single factor analysis,and ulcer size, ulcer location, concomitant usage of drugs, smoking and condition of Helicobacterpylori （H .pylori ）infection at the end of follow-up were found to be correlated with recurrence of peptic ulcer in the elderly.After adjusting age and gender,the potential risk factors were analyzed by a Logistic stepwise regression model.Smoking （OR = 1 .788,P = 0.001 ）,combined medication （OR=6.202,P =0.015 ）,ulcer size （OR =2.697,P =0.032 ）and condition of H .pylori infection at the end of follow-up （OR=43.784,P =0.007）were found to be correlated with recurrence of peptic ulcer in the elderly.Conclusion Smoking,combined medication,ulcer size and condition of H .pylori infection at the end of follow-up have an impact on peptic ulcer recurrence in the elderly.

关 键 词：老年人 消化性溃疡 复发因素 螺杆菌 幽门 吸烟 抗复发治疗 

分 类 号：R573.1[医药卫生—消化系统]