纳米炭在乳腺癌改良根治术中的临床应用价值  

Clinical significance of carbon nanoparticles in breast cancer lymphadenectomy

作　　者：刘汇明[1] 丁洪华[1] 燕璐璐 刘世江[1] 郑丽萍[1] 刘翠云[3] 

机构地区：[1]寿光市人民医院普外三科,山东省寿光262700 [2]寿光市人民医院放射科,山东省寿光262700 [3]寿光市人民医院病理科,山东省寿光262700

出　　处：《中国基层医药》2016年第13期1967-1969,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山东省潍坊市科技计划项目（2015WS117）

摘　　要：目的：探讨乳腺癌改良根治术前肿瘤周围多点注射纳米炭对≤5 mm淋巴结（微小淋巴结）清扫的临床意义。方法50例患者术前空芯针穿刺活检证实为乳腺癌，采用数字表法随机分为两组，25例术前24 h 肿瘤周围注射纳米炭后行乳腺癌改良根治术（研究组），25例行常规乳腺癌改良根治术（对照组），对切除微小淋巴结的数量及阳性微小淋巴结的数量进行对比。结果研究组、对照组每例平均清扫微小淋巴结（23．60±4．61）枚、（14．60±5．16）枚，差异有统计学意义（t ＝3．47，P ＜0．05）。研究组、对照组每例平均清扫阳性微小淋巴结（5．80±1．49）枚、（2．89±1．66）枚，差异有统计学意义（t ＝2．91，P ＜0．05）。结论乳腺癌改良根治术前肿瘤周围多点注射纳米炭不仅可以清除更多微小淋巴结，而且可以清除更多转移的阳性微小淋巴结，从而提高根治程度，并对患者术后病理分期及术后综合治疗起到重要指导作用。Objective To evaluate the clinical application value of active carbon nanoparticles to guide breast cancer tiny lymphadenectomy.Methods 50 patients with breast cancer were enrolled in the study and were divided into two groups by random number table.Active carbon particle was injected locally to guide the regional lymph nodes dissection in 25 cases as study group,and the traditional method was performed in 25 cases as observation group.Numbers of dissected lymph nodes were compared between two groups.Results The average number of eliminated small lymph nodes in the study group was dramatically more than that in the observation group[（23.60 ±4.61）vs. （14.60 ±5.16）,t =3.47,P 〈0.05].There was significant difference between the study group and the observation group in the small ambulant lymph nodes[（5.80 ±1.49）vs.（2.89 ±1.66）,t =2.91,P 〈0.05）].Conclusion Active carbon injected locally can eliminate not only more small lymph nodes,but also more small ambulant lymph nodes.

关 键 词：纳米管 碳 淋巴结切除术 乳腺肿瘤 乳房切除术 改良根治性 

分 类 号：R737.9[医药卫生—肿瘤]