肝炎肝硬化外周血细胞变化与乳酸脱氢酶的相关性分析  

Correlation of the Peripheral Blood Cells Changes and Lactate Dehydrogenase Levels in Hepatitis and Cirrhosis

作　　者：景晔[1] 陈银海[1] 徐和福[1] 杨辉[1] 王莉[1] 

机构地区：[1]北京军区天津疗养院,天津300381

出　　处：《解放军预防医学杂志》2016年第3期379-381,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的探讨肝炎肝硬化患者外周血细胞变化与血清乳酸脱氢酶水平的相关性。为早期发现骨髓病态造血、早期诊治及判断预后提供依据。方法对227例肝炎肝硬化患者的外周血血红蛋白、中性粒细胞、血小板、网织红细胞、血清丙氨酸转移酶(ALT)、血清乳酸脱氢酶(LDH)进行检测和分析。结果肝炎肝硬化LDH水平与外周血三系血细胞水平呈显著负相关(r=-0.789,P<0.05),而与网织红细胞增高呈显著正相关(r=0.576,P<0.05),与预后不良呈显著正相关(r=0.778,P<0.05)。结论肝炎肝硬化患者血清LDH升高可以作为早期病态造血的客观指标,是早期防治及判断预后的依据。Objective To explore the correlation of peripheral blood cells changes and serum lactate dehydrogenase levels in patients with hepatitis cirrhosis, in order to detect early pathological bone marrow hematopoietic and to provide evidence for early diagnosis and treatment and prognosis. Method The hemoglobin, neutrophile, platelet, granulofilocyte, serum alanine aminotransferase （ALT） as well as serum lactic dehydrogenase （LDH） activity of Peripheral Blood （PB） from 227 hepatitis hepatocirrhosis patients and 50 health controls were analyzed. Relults The LDH levels of hepatitis, cirrhosis patients had negatively correlation with peripheral blood three-line cytopenia （r =-0. 789, P〈0.05 ）, and positively correlated with increased reticulocyte （ r = 0. 576, P〈0.05 ）, significantly associated with poor prognosis （ r = 0. 778, P〈 0.05 ）. Conclusion Hepatitis, liver cirrhosis patients with elevated serum LDH can be used as objective indicators of early pathological hematopoietic, and the evidence for early prevention and treatment and prognosis.

关 键 词：肝炎肝硬化 病态造血 乳酸脱氢酶 血细胞 

分 类 号：R575.1[医药卫生—消化系统]