定量MRI动态增强成像定量参数和灌注参数在宫颈癌微循环评价的价值  

Evaluation of Cervical Cancer Microcirculation with Duantitative Parameters and Perfusion parameters of MRI Quantitative Dynamic Contrast Enhanced Imaging

作　　者：孙俊旗[1,2] 吴光耀[2] 单菲菲[1] 杨昊[2] 王科[2] 

机构地区：[1]汕头大学医学院附属粤北人民医院影像科,广东韶关512026 [2]武汉大学中南医院影像科,湖北武汉430071

出　　处：《牡丹江医学院学报》2016年第4期1-5,共5页Journal of Mudanjiang Medical University

基　　金：国家自然科学基金资助项目(81171315;81227902);广东省韶关市科技计划项目[韶科(卫)2015cx/k23]

摘　　要：目的探讨MRI定量动态增强成像的定量参数及灌注参数评价宫颈癌微循环变化的价值。方法 30例宫颈癌组、20例子宫肌瘤组、22例正常宫颈组进行MRI常规序列及定量动态增强成像序列成像,通过第三方软件后处理得到定量参数(K^(trans)、K_(ep)、V_e)和灌注参数(BV、BF、MTT)。然后进行三组间、组内统计学分析、绘制ROC曲线,确定阈值及诊断效能。结果MRI定量动态增强成像的K^(trans)、K_(ep)、BF、BV在宫颈癌组、肌瘤组、正常宫颈组组间有统计学差异(P<0.05),K^(trans)、K_(ep)在宫颈癌组与肌瘤组有显著地统计学差异(P<0.01),K^(trans)、K_(ep)、BF、BV在宫颈癌组和正常宫颈组有统计学差异(P<0.05),Vp在肌瘤组和正常宫颈组有统计学差异(P<0.05),V_e和MTT在组间和组内无统计学差异,ROC曲线显示K^(trans)值曲线下面积最大及其阈值的诊断效能最高。结论 MRI定量动态增强成像可以定量化的诊断及鉴别宫颈良恶性病变,显示肿瘤微循环定量信息及灌注信息,在肿瘤定性及疗效评估方面具有广阔的应用前景。Objective To evaluate cervical microcirculation with quantitative parameters and perfusion parameters of quantita -tive dynamic contrast-enhanced MRI imaging .Methods Routine MRI sequences and quantitative dynamic contrast -enhanced MRI imaging were made in 30 cases of cervical cancer ,20 cases of uterine fibroids group ,22 cases of normal cervical group .MRI image is processed using third-party software to obtain quantitative parameters （ Ktrans、Ve、Vp） and perfusion parameters （ BV、BF、MTT） .Be-tween groups and within the group of statistical analysis were performed ,ROC curve was drawn ,the threshold value and the diagnostic efficacy were determined .Results Ktrans ,Kep ,BF and BV values of quantitative dynamic contrast -enhanced MRI imaging were statis-tical difference between cervical cancer ,uterine fibroids group,normal cervical group（ P〈0.05）.Ktrans and Kep values were significantly statistical difference between cervical cancer group and uterine fibroids group （ P〈0.01）.Ktrans,Kep,BF and BV values were statistical difference between cervical cancer group and normal cervical group （ P〈0.05）.Vp value was statistical different between normal cer-vical and uterine fibroids group （ P〈0.05）.No significant difference in Ve and MTT between and within group .ROC curve showed that Ktrans value was the maximum under ROC curve and its threshold value was the highest diagnostic efficacy .Conclusion Quanti-tative dynamic contrast -enhanced of MRI imaging can be quantitative diagnosis and differential diagnosis of benign and malignant le -sions of the cervix ,and show the tumor microcirculation and perfusion information .

关 键 词：宫颈癌 定量动态增强成像 磁共振成像 微循环 灌注 

分 类 号：R73[医药卫生—肿瘤]