氨磺必利对慢性阴性症状为主精神分裂症患者的临床疗效分析  

Clinical analysis of efficacy of Amisulpride on chronic negative symptoms of patients with schizophrenia

作　　者：刘庆梅[1] 罗鱼 胡亚荣[1] 易军[1] 万其容[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院精神科,湖北武汉430077

出　　处：《中国民康医学》2016年第10期1-3,33,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察氨磺必利治疗以慢性阴性症状为主的精神分裂症患者的疗效和安全性。方法:将96例慢性阴性症状为主的精神分裂症患者随机分为观察组和对照组,每组各48例。观察组患者给予氨磺必利治疗;对照组患者给予利培酮治疗。治疗前后,用阴性症状评定量表(SANS)、治疗中出现的症状量表(TESS)评定两组患者的疗效和不良反应。结果:治疗12周后,观察组和对照组组患者的治疗有效率分别为62.5%和56.3%;SANS总分在第4、8、12周末与治疗前比较明显下降,差异有统计学意义(P<0.01)。治疗后,两组患者的SANS各因子分值均有不同程度的下降,差异有统计学意义(P<0.01);治疗后第8,12周末,两组患者兴趣社交缺乏、注意障碍及第12周末情感淡漠评分比较,观察组患者的减分高于利培酮组,差异有统计学意义(P<0.05或P<0.01)。结论:氨磺必利与利培酮总体疗效相似,氨磺必利对阴性症状患者的疗效更好,对EPS、泌乳素和体重的影响更小。Objective： To observe efficacy and safety of Amisulpride in treatment of schizophrenics with predominantly chronic negative symptoms. Methods： 96 patients with predominantly chronic negative symptoms of schizophrenia were randomly divided into48 cases of Amisulpride group（ observation group） and 48 cases of Risperidone group（ control group）. The scale for the assessment of negative symptoms（ SANS） and treatment emergent symptom scale（ TESS） were used to assess the efficacy and side effects before and after the treatment. Results： 12 weeks after the treatment,the effective rates of observation group and control group were 62.5% and56.3%,respectively. The SANS total score decreased significantly at the 4th,8th,and 12 th weekend than baseline,and the differences were statistically significant（ P〈0.01）. The each factor score of SANS showed varying degrees of decline after the treatment,and the difference was statistically significant（ P〈0.01）. The lack of social interest and attention disorder of the two groups appeared at the8 th and 12 th weekend. At 12 th weekend,the points deducted of apathy of observation group were greater than those of control group,and the difference was statistically significant（ P〈0.05 or P〈0.01）. Conclusions： The overall effect of Amisulpride is similar to risperidone. Amisulpride is much more effective on negative symptoms,and the impact on EPS,prolactin and weight are smaller.

关 键 词：氨磺必利 利培酮 精神分裂症 阴性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]