利培酮联合丙戊酸镁治疗伴有幻觉的精神分裂症患者的疗效观察  

A comparative study on risperidone orally disintegrating tablets and retard tablets of magnesium valproate treatment in hallucination of schizophrenia

作　　者：王小全[1] 马素杰[1] 穆小梅 周海晓[1] 

机构地区：[1]甘肃省天水市精神病医院,甘肃天水741000

出　　处：《中国民康医学》2016年第10期4-6,10,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察利培酮联合丙戊酸镁治疗伴有幻觉的精神分裂症患者的疗效及安全性。方法:将80例符合ICD-10精神与行为障碍分类F20的精神分裂症患者按入院前后配对设计随机分为研究组和对照组,每组各40例。研究组患者给予丙戊酸镁缓释片联合利培酮口崩片治疗;对照组患者单用给予利培酮口崩片治疗。治疗观察6周,比较治疗前后,两组患者每周评定阳性与阴性症状量(PANSS),同期评定副反应量表(TESS)和锥体外系反应量表(RSESE)的评定结果;以PANSS中(幻觉行为)P3分减分值评定两组患者的疗效。结果:研究组患者,有效36例(90%),无效4例(10%);对照组患者,有效29例(72.5%),无效11例(27.5%)。两组患者间差异有统计学意义(x2=4.02,P<0.05)。PANSS量表P3分,研究组患者第1周有显著下降(P<0.05);对照组患者在第2周末时有显著下降(P<0.05);研究组患者的阳性症状量表分值,在第1周有明显下降(P<0.05),其他因子分及总分在第2周有显著下降(P<0.05);激活性、攻击性分值在第1周有显著下降(P<0.05),其他分值于第2周有显著下降。对照组患者的各症状群分值于第2周或第3周均有显著下降(P<0.05)。结论:利培酮联合丙戊酸镁比单用利培酮对精神分裂症的幻觉症状改善作用更明显。Objective： Observation of risperidone orally disintegrating tablets combined treatment with retard tablets of magnesium valproate of the efficacy and safety in hallucination of schizophrenia. Methods： 80 schizophrenic patientsmet ICD-10 criteria for schizophrenia and haiiucination with schizophrenia were randomly divided in to groups. With one treated with retard tablets of magnesium valproate combined treatment risperidone orally disintegrating tablets and the other with only using risperidone orally disintegrating tablets. Effects and side effects and social function were assessed with Positive And Negative Syndrome Scale（ PANSS）,Treatment Emergent Symptoms Scale（ TESS） and the A Rating Scale for Extrapyramidal Side Effects（ RSESE） respectively beforeand after 2,4,6weeks treatment. Efficacy and safety of the treatment were assessed respectively by Hallucinatory behavior（ p3） points reduction in PANSS. Results： The clinical efficiency of experimental and control groups were 90% and 72.5%,respectively. The difference was significant between the groups（ P〈0.05）. P3 in PANSS scale points of the clinical efficiency of experimental in the first week has dropped significantly（ P〈0.05）,While the control group decreased significantly in the second week（ P〈0.05） .Positive symptoms scale score of the clinical efficiency of experimental in the first week has decreased obviously（ P〈0.05）,While the control group decreased significantly in the second week（ P〈0.05）; Team＇s activation and aggressive factor points of the clinical efficiency of experimental in the first weekend have declined significantly（ P〈0.05）,While the control group decreased significantly in the second week（ P〈0.05）. Conclusions： Risperidone combined valproic acid magnesium combination than risperidone for schizophrenia hallucinations effect more apparent.

关 键 词：精神分裂症 幻听 利培酮 丙戊酸镁缓释片 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]