肝纤维化程度对行腹腔镜下ALPPS术巨块型原发性肝癌患者临床指标的影响  

Influence of Hepatic Fibrosis Degree on Remnant Liver Volume,Operation Interval Time and Liver Function Index of Patients with Giant Block Type Liver Cancer with ALPPS by Laparoscopic Resection

作　　者：侯俊光[1] 沈颜芹[2] 

机构地区：[1]山东省临朐县人民医院普外二科,临朐262600 [2]山东省临朐县人民医院超声科,临朐262600

出　　处：《中国医药导刊》2016年第6期602-603,606,共3页Chinese Journal of Medicinal Guide

摘　　要：目的：探讨肝纤维化程度对行腹腔镜下ALPPS术巨块型原发性肝癌患者残肝体积、手术间隔时间及肝功能指标的影响。方法：选取我院2013年4月～2015年4月收治合并肝硬化原发性肝癌行腹腔镜下ALPPS术患者共42例,其中,轻中度肝纤维化患者共28例设为A组,重度肝纤维化患者共14例设为B组;比较两组患者手术完成率,残肝体积增加情况、手术间隔时间及手术前后肝功能指标等。结果：A组患者手术完成率显著高于B组,差异具有显著性（P〈0.05）;A组患者残肝体积增加情况明显优于B组,差异具有显著性（P〈0.05）;A组患者手术间隔时间明显短于B组,差异具有显著性（P〈0.05）;同时A组患者术后24h肝功能指标均明显优于B组,差异具有显著性（P〈0.05）。结论：相较于重度肝纤维化,合并轻中度肝纤维化巨块型原发性肝癌患者行腹腔镜下ALPPS术治疗在增加残肝体积、缩短手术间隔及保护肝脏功能方面优势明显。Objective： To investigate the influence of hepatic fibrosis degree on remnant liver volume,operation intervaltime and liver function index of patients with giant block type liver cancer with ALPPS by laparoscopic resection.Methods：42patients with giant block type liver cancer with ALPPS by laparoscopic resection were chosen in the April 2013 to April 2014 inour hospital and divided into both group including A group （28 patients） with shepatic fibrosis for mild and moderate degree andB group （14 patients） with hepatic fibrosis for severe degree;and the operation completion rate,the increasing degree of residualliver volume,operation interval time and liver function indexes before and after surgery of both groups were compared.Results：The operation completion rate of A group was significantly higher than B group（P〈0.05）.The increasing degree of residual livervolume of A group was significantly better than B group（P〈0.05）.The operation interval time of A group was significantly shorterthan B group（P〈0.05）.The liver function indexes in 24h after surgery of A groups was significantly better than B group（P〈0.05）.Conclusion：Compared with hepatic fibrosis for severe degree,ALPPS by laparoscopic resection in treatment of patients withgiant block type liver cancer and shepatic fibrosis for mild and moderate degree can efficiently increase the volume of remnantliver,shorten the operation interval time and protect the liver function.

关 键 词：肝纤维化 ALPPS 巨块型原发性肝癌 肝功能 

分 类 号：R735.7[医药卫生—肿瘤] R575.2[医药卫生—临床医学]