卵巢上皮性癌中VEGF-C和TrkB蛋白表达的相关性及意义  

The correlation and significance of VEGF-C and Trk B protein expression in epithelial ovarian carcinoma

作　　者：龙琼先 唐治蓉 吴才良 彭勇 

机构地区：[1]南充市中心医院病理科川北医学院第二临床医学院,四川南充637000 [2]南充市中心医院妇产科川北医学院第二临床医学院,四川南充637000

出　　处：《现代肿瘤医学》2016年第16期2579-2583,共5页Journal of Modern Oncology

基　　金：南充市应用技术研究与开发(编号:12A0069)

摘　　要：目的:探讨血管内皮生长因子-C(VEGF-C)、失巢凋亡抑制因子酪氨酸激酶受体B(Trk B)在卵巢上皮性癌发生、发展及淋巴结转移中的表达及相关性研究。方法:采用免疫组织化学法检测106例原发性卵巢上皮性癌、40例交界性上皮性肿瘤及40例良性上皮性肿瘤组织中VEGF-C和Trk B蛋白的表达,分析其表达与临床病理特征的关系。结果:VEGF-C在卵巢癌中的表达率为82.1%(87/106),明显高于良性肿瘤组32.5%(13/40)和交界性肿瘤组52.5%(21/40)(P<0.05);Trk B在卵巢癌中的表达率为74.5%(79/106),明显高于良性肿瘤组7.5%(3/40)和交界性肿瘤组27.5%(11/40)(P<0.05);在卵巢癌组中,VEGFC和Trk B蛋白的表达呈正相关(r=0.574,P<0.05)。在肿瘤分化越低、临床分期越高、脉管内有癌栓及有淋巴结转移的卵巢癌组织中,Trk B和VEGF-C蛋白的阳性率越高。结论:VEGF-C可能与Trk B在卵巢癌的发生发展过程中发挥着协调作用,两者联合检测可作为判断卵巢癌恶性程度、侵袭、预后的重要指标。Objective：To evaluate the correlation of VEGF - C and TrkB protein expression and explore its role in the in epithelial ovarian carcinoma occurrence and development. Methods：VEGF - C and TrkB protein were detected in 106 cases of epithelial ovarian carcinoma,40 cases of borderline tumors and 40 cases of benign tumors by immuno-histochemistry. Results：In the ovarian carcinoma,the positive expression rate of VEGF - C protein was 82. 1% . The rate was higher than that in benign tumors（32. 5% ）and borderline tumors（52. 5% ,P ﹤ 0. 05）. In epithelial ovarian carcinoma,the positive expression rate of TrkB was 74. 5% ,higher than that in benign tumors（7. 5% ）and borderline tumors（27. 5% ,P ﹤ 0. 05）. In ovarian carcinoma,the VEGF - C expression was positively correlated with the TrkB（r= 0. 574,P ﹤ 0. 05）. In poor differentiation,high clinical stage,lymph node metastasis and in the vascular invasion group,the high expression rate of VEGF - C and TrkB were observed（P ﹤ 0. 05）. Conclusion：The high expression of VEGF - C and TrkB may exhibit synergistic effect on the development of ovarian carcinoma and simultaneously pro-mote malignant development of ovarian carcinoma. The combined detection of two protein can be considered as progno-sis indicator to determine the degree of malignancy of ovarian cancer.

关 键 词：卵巢肿瘤 VEGF-C TRKB 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]