氟西汀联合舒肝解郁胶囊治疗伴有失眠的抑郁症疗效及安全性观察  

Effectiveness of fluoxetine combined with Shuganjieyu capsule on depressed patients with insomnia

作　　者：张美霞[1] 王丽娜[1] 王秀娟[1] 孙欠欠[1] 王长虹[1] 

机构地区：[1]新乡医学院第二附属医院早期干预一科,河南新乡543002

出　　处：《新乡医学院学报》2016年第6期489-491,496,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨氟西汀联合舒肝解郁胶囊治疗伴有失眠症状的抑郁症患者的疗效及安全性。方法选择轻-中度伴失眠的抑郁症患者58例,随机分为观察组和对照组,每组29例。观察组患者给予氟西汀分散片联合舒肝解郁胶囊治疗,对照组仅给予氟西汀分散片治疗,共6周。应用汉密尔顿抑郁量表(HAMD)和匹兹堡睡眠质量指数(PSQI)评定2组患者疗效,不良反应量表(TESS)评价2组患者不良反应情况。结果治疗6周末,观察组患者治疗有效率为93.1%(27/29),对照组患者治疗有效率为82.2%(24/29),2组比较差异有统计学意义(P<0.05)。治疗前2组患者HAMD评分比较差异无统计学意义(P>0.05),治疗2、4、6周时,观察组患者HAMD评分较对照组显著降低,减分率较对照组显著升高(P<0.05)。治疗前观察组和对照组患者PSQI评分差异无统计学意义(P>0.05),治疗2、4、6周时,观察组患者PSQI评分较对照组显著降低,减分率较对照组显著升高(P<0.05)。观察组不良反应发生率(27.6%)与对照组(31.0%)比较差异无统计学意义(P>0.05)。结论与单用氟西汀相比,氟西汀联合舒肝解郁胶囊治疗伴有失眠的轻-中度抑郁症患者疗效更显著,起效更快,对失眠症状效果更好,且不增加不良反应发生率。Objective To investigate the effectiveness and side-effect of fluoxetine combined with Shuganjieyu capsule for depressed patients with insomnia. Methods A total of 58 light to moderate depressed patients with insomnia were chosen and randomly divided into observation group and control group,with 29 cases in each group. The patients in observation group were treated with fluoxetine combined with Shuganjieyu capsule while the patients in control group were treated with fluoxetine only for 6 weeks. Hamilton depression rating scale（ HAMD） and Pittsburgh sleep quality index（ PSQI） were used to evaluate the curative effect of the patients in the two groups,and treatment emergent symptom scale（ TESS） was used to evaluate adverse reactions of patients in the two groups. Results After the treatment of 6 weeks,the effective rate in observation group was 93. 1%,which was 82. 2% in control group,and there was significant difference between the two groups（ P〈0. 05）. The HAMD score between the two groups before treatment had no significant difference（ P〉0. 05）,and the HAMD score decreased while the deducted rate increased significantly compared with control group after the treatment for 2,4 and 6 weeks（ P〈0. 05）. Before treatment,there was no significant difference of PSQI score between research group and control group（ P〈0. 05）. The PSQI score decreased while the deducted rate increased significantly compared with control group after the treatment for 2,4 and 6 weeks（ P〈0. 05）. The incidence of adverse reactions was 27. 6% in observation group and 31. 0% in control group,respectively. There was no significant difference between the two groups（ P〉0. 05）. Conclusion Fluoxetine combined with Shuganjieyu capsule on mild-to-moderate depressed patients with insomnia has more apparent,work faster and better effect on insomnia than fluoxetine,and hasn＇t increase the risk of adverse reactions.

关 键 词：氟西汀 舒肝解郁胶囊 抑郁症 失眠 

分 类 号：R749.4[医药卫生—神经病学与精神病学]