下颌骨朗格汉斯细胞组织细胞增多症的影像表现与病理对照(2例报告并文献复习)  

Radiologic and Pathologic Correlation of the Langerhans Cell Histiocytosis in Mandible:Two Cases Reporte and Literature Review

作　　者：马斌[1,2] 尹建军[1,2] 

机构地区：[1]湖北省黄石市中心医院(湖北理工学院附属医院)放射科,435000 [2]湖北省黄石市中心医院(湖北理工学院附属医院)肾脏疾病发生机干预湖北省重点实验室,435000

出　　处：《临床放射学杂志》2016年第6期972-975,共4页Journal of Clinical Radiology

摘　　要：目的探讨下颌骨朗格汉斯细胞组织细胞增多症(Langerhans cell histiocytosis,LCH)的影像表现和病理特征。方法回顾性分析经病理证实的2例下颌骨LCH患者的影像及临床病理资料,并复习相关文献。结果2例病灶均位于下颌骨升支,其中1例累及下颌角。下颌骨骨质呈溶骨性及膨胀性破坏并见周围软组织肿块。病灶边界清晰,密度不均匀,内见低密度囊变坏死区;增强扫描后呈轻中度不均匀强化。病理示2例病灶内均含有丰富的朗格汉斯细胞组织细胞,见散在嗜酸性粒细胞浸润;免疫组织化学示CD1a、S-100及CD68呈阳性。结论下颌骨LCH的影像学表现虽然缺乏特征性,但发生于小儿患者下颌骨升支溶骨性及膨胀性的肿块应考虑该病。确诊仍需结合病理学及免疫组织化学检查。Objective To investigate the imaging findings and pathologic features of the Langerhans Cell Histiocytosis（LCH） in the mandible.Methods The imaging and clinic-pathologic data of two patients with LCH in the mandible confirmed by pathology in retrospectively analyzed and related literatures reviewed.Results The two tumors were located in the mandibular ramus,one of which involved the mandibular angle.Mandibular were osteolytic and swelling bony destruction with surrounding soft tissue masses formed.The lesions were clear boundary,uneven density including low density cyst degeneration and necrosis; after enhanced scanning,they showed mild-moderate uneven reinforcement.The pathological findings showed that the tumors contained rich Langerhans cell histiocytosis with scattered eosinophil infiltration; CD1 a,S-100 and CD68 were positive on immunochemistry staining.Conclusion Although the LCH in the mandible is not of significant imaging characteristics,the osteolytic and swelling bony destruction with soft tissue masses of the mandible in children should suspect for LCH.Final diagnosis should be based on histopathology and immunohistochemistry examinations.

关 键 词：下颌骨 朗格汉斯细胞组织细胞增多症 体层摄影术 X线计算机 病理 

分 类 号：R782.2[医药卫生—口腔医学] R816.98[医药卫生—临床医学]