MiRNA-221/222在甲状腺癌中的功能研究  

Function of MiRNA-221/222 in Thyroid Cancer

作　　者：王云生[1,2] 高庆军[1] 赵代伟[3] 

机构地区：[1]贵州医科大学附属医院甲状腺外科,贵州贵阳550004 [2]贵州医科大学,贵州贵阳550004 [3]贵州医科大学第二附属医院甲状腺外科,贵州凯里556000

出　　处：《中国普外基础与临床杂志》2016年第7期887-890,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结miRNA-221/222与甲状腺癌之间关系的研究现状,探讨其在甲状腺癌诊断与治疗中的重要作用。方法检索并筛选近年来国内外发表的有关miRNA-221/222与甲状腺癌诊治的文献并对其进行综述。结果 miRNA-221/222是甲状腺癌特异性和敏感性较高的肿瘤标志物,对甲状腺癌的诊断、治疗及预后判断具有重要意义。结论 miRNA-221/222不但与甲状腺癌的诊断相关,也为甲状腺癌的基因治疗提供了新的研究方向和方法。Objective To summarize the domestic and abroad articles related to the research on the relation between miRNA-221/222 and thyroid cancer, and explore the important effects of miRNA-221/222 in diagnosis and treatment of thyroid cancer. Methods Domestic and international publications involving the relationship ofmiRNA-221/222 to thyroid cancer were screened and reviewed. Results MiRNA-221/222 is a tumor marker with high specificity and sensitivity in thyroid cancer. It has important significance for diagnosis, treatment and prognosis of thyroid cancer. Conclusion MiRNA-221/222 is not only related to diagnosis of thyroid cancer, but also have provided a new research direction and method for gene therapy of thyroid cancer.

关 键 词：甲状腺癌 MIRNA 肿瘤标志物 

分 类 号：R736.1[医药卫生—肿瘤]