Hippo-YAP信号通路与肿瘤关系的研究进展  

Research progress of relation between Hippo-YAP signaling pathway and tumor

作　　者：李道胜[1] 班媛媛[2] 

机构地区：[1]山东省泰安市中心医院病理科,271000 [2]山东省泰安市中心医院老年病一科,271000

出　　处：《肿瘤研究与临床》2016年第6期429-432,共4页Cancer Research and Clinic

摘　　要：Hippo-YAP信号通路作为肿瘤抑制的一个重要信号通路，具有调节器官大小和维持细胞增殖与凋亡的动态平衡等功能。研究发现YAP可以通过影响细胞的增殖、凋亡等从而参与肿瘤的发生、发展。文章就Hippo-YAP信号通路在肿瘤中的作用及其机制进行综述。The Hippo-YAP signaling pathway, an important signaling pathway of tumor suppressor, is featured by functions of adjusting the organ size and maintaining the dynamic balance between cell proliferation and apoptosis. Several researches have revealed that the Hippb-YAP signaling pathway can affect cell proliferation and apoptosis so as to participate in the development of tumor. This paper Will review the effect and mechanism of Hippo-YAP signaling pathway in tumor.

关 键 词：肿瘤 Hippo信号通路 YAP蛋白 

分 类 号：R730.2[医药卫生—肿瘤]