包含微丝的细胞流固耦合模型及其力学响应  

The Fluid Solid Coupling Model Including the Actin and Its Mechanical Response

作　　者：柯文俊[1] 刘泽佳[1] 汤立群[1] 董守斌[2] 

机构地区：[1]华南理工大学土木与交通学院,广州510641 [2]华南理工大学计算机科学与工程学院,广州510641

出　　处：《科学技术与工程》2016年第19期160-163,共4页Science Technology and Engineering

基　　金：国家自然科学基金项目(11272124;11472109);广东省科技厅项目(2015B010131009)资助

摘　　要：为研究微丝对细胞变形的影响,利用Abaqus建立包含微丝结构的细胞流固耦合模型:其中细胞膜、细胞核和微丝为固体,细胞质为液体。考虑对称性,以细胞模型的一半建立有限元计算模型,采用显式求解器进行模拟计算。仿真结果显示,在细胞压缩变形的情况下,细胞整体刚度随着压缩位移增加而增加,即表示在压缩相同的位移,所需要施加在细胞的荷载更大;对比无微丝的细胞,微丝的存在使细胞刚度大大增加,细胞抵抗外界荷载的能力得到增强;同时微丝排列方向会对细胞的抵抗能力造成一定的影响。A fluid-solid coupling finite element model of a cell was established by ABAQUS to study the effect of the actin cytoskeleton on the cell deformation,which contains the solid cell membrane,nucleus and actin cytoskeleton,and liquid cytoplasm.Considering the symmetry,one half of the cell model was used in the numerical simulation.The simulation results show that the cell stiffness increases with the increase of cell compression deformation,which meaned that more loads were applied on the cell when the same displacements were compressed on the cell.Compared with no cell microfilament,the existence of microfilament can make the cell whole stiffness increasing greatly and make the cell having more resistance ability.What＇s more,the angle change of microfilament makes some effects on the resistivity of cell.

关 键 词：细胞模型 微丝 流固耦合 

分 类 号：Q66[生物学—生物物理学]