顶空进样GC-SIM-MS测定硝唑尼特中溶剂残留甲醇含量  

Determination of Methanol Solvent Residue in Nitazoxanide with Headspace GC-SIM-MS

作　　者：吴清盛[1] 茅小燕[1] 孙丽东[1] 

机构地区：[1]浙江育英职业技术学院,浙江杭州310018

出　　处：《分析测试技术与仪器》2016年第2期120-123,共4页Analysis and Testing Technology and Instruments

摘　　要：利用气相色谱-选择离子监测质谱联用仪(GC-SIM-MS)测定硝唑尼特样品中溶剂残留甲醇的含量,顶空进样,温度为70℃,时间为20 min.SIM定量离子m/z 32,参考离子m/z 31,30和29.甲醇质量浓度在0.5~100μg/m L内呈良好的线性(R^2=0.999 92).方法相对标准偏差为2.49%~4.85%,样品加标回收在94.5%~102.8%之间,检测限为0.5μg/m L,符合定量分析的要求.The determination of methanol solvent residues in the samples of nitazoxanide using gas chromatography-selected ion monitoring-mass spectrometry（ GC-SIM-MS） has been curried out. A peak area standard curve method is used as the quantitative method. The heating temperature of the sample was 70 ℃,with an equilibrium time of 20 min,SIM m / z 32,m / z 31,30,and 29. The concentration of toluene was linear in the range of 0. 5 ~ 100 μg / mL（ R^2= 0. 999 92）. The relative standard deviation of the method was 2. 49% ~ 4. 85%,the recovery was between 94. 5% ~ 102. 8%,the detection limit was 0. 5 μg / m L,which were in accordance with the requirement of quantitative analysis.

关 键 词：硝唑尼特 甲醇 顶空进样 气相色谱-选择离子监测质谱联用仪 

分 类 号：O657.33[理学—分析化学]