全胸腔镜肺叶切除联合淋巴结清扫术治疗高龄非小细胞肺癌患者的疗效观察  

Curative Effect of Thoracoscopic Lobectomy Combined with Lymph Node Dissection in the Treatment of Advanced Age Patients with Non Small Cell Lung Cancer

作　　者：马幸生[1] 钟钏[1] 尹松林[2] 郭孟刚[1] 冯麓洁 

机构地区：[1]遂宁市中心医院胸外科,四川遂宁629000 [2]川北医学院附属医院急诊科,四川南充637000 [3]遂宁市中心医院检验科,四川遂宁629000

出　　处：《现代生物医学进展》2016年第21期4103-4105,4092,共4页Progress in Modern Biomedicine

摘　　要：目的:研究全胸腔镜肺叶切除联合淋巴结清扫术治疗高龄非小细胞肺癌(NSCLC)患者的临床疗效。方法:回顾性分析108例我院2009年2月到2013年2月接受全胸腔镜肺叶切除联合淋巴结清扫术治疗的老年NSCLC患者的临床病历,记录患者的基本资料及相关手术指标(手术时间、术中出血量、术后输血量、术后住院时间、胸管放置时间、胸液总量、止痛药使用次数、术后并发症、清除淋巴结情况),随访两年,了解其生存情况。结果:≥70岁患者30例(高龄组),<70岁患者78例(非高龄组),两组患者年龄及术前肺功能差异均有统计学意义(P<0.05),但两组患者性别、病理类型、病理分期和基础疾病均无统计学意义(P>0.05)。两组相关手术指标比较差异均无统计学差异(P>0.05)。高龄患者与非高龄患者的中位生存时间(30.5月vs36月)、1年生存率(96.9%vs98.1%),2年生存率(75.2%vs80.3%)比较差异无统计学意义(P>0.05)。结论:高龄NSCLC患者与非高龄者的手术指标及两年预后大致相同,因此采用全胸腔镜肺叶切除联合淋巴结清扫术治疗高龄非小细胞癌患者并不会增加手术风险。Objective： To study the clinical efficacy of thoracoscopic lobectomy combined with lymph nodes dissection in the treatment of advanced age patients with non small cell lung cancer （NSCLC）. Methods： Retrospectively analyzed the clinical medical records of 108 cases of elderly patients with NSCLC who were treated with thoracoscopic lobectomy combined with lymph nodes dissec- tion in our hospital from February 2009 to February 2013, recorded the basic data and the related operation indexes（operation time, intra- operative blood loss, postoperative blood transfusion, postoperative hospital stay, chest tube placement time, the total pleural fluid, the use of analgesics, postoperative complications,removal of lymph nodes） of the patients, followed up for two years, and known their sur- vival situation. Results： 30 cases of patients were ≥ 70 years old （advanced age group）, and 78 cases of patients were 〈70 years old（non advanced age group）. The age and preoperative pulmonary function between the two groups were significant differences （P〈0.05）, but there were no significant difference in gender, pathological types, pathological stages and basic diseases of two groups （P〉0.05）. The re- lated operation indexes between two groups had no significant difference（P〉0.05）. The median survival time（30.5 months vs 36 months）, 1 year survival rate（96.9% vs 98.1%） and 2 year survival rate（75.2% vs 80.3%） between advanced age group and non advanced age group had no significant difference （P〉0.05）. Conclusions： The operation indexes and the prognosis during two years of advanced age and non advanced age NSCLC patients are roughly the same, therefore, advanced age NSCLC patients is able to treated with thoracoscopic lobectomy combined with lymph nodes dissection without increaseing the risk of operation.

关 键 词：非小细胞肺癌 全胸腔镜肺叶切除术 淋巴结清扫术 高龄 

分 类 号：R734.2[医药卫生—肿瘤]