长链非编码RNA在乳腺癌中的研究进展  

Progress on the Relationship between Breast Cancer and Long Non-coding RNA

作　　者：李稳[1] 马欣[1] 汪静[1] 王竹[1] 陈玉娟[1] 

机构地区：[1]四川大学华西医院甲状腺乳腺外科,四川成都610041

出　　处：《现代生物医学进展》2016年第21期4174-4176,4180,共4页Progress in Modern Biomedicine

基　　金：四川省科技厅科技支撑项目(0040205301C24);吴阶平医学基金项目(312130022)

摘　　要：乳腺癌是女性最常见的恶性肿瘤之一,且其发病率呈逐年上升的趋势,尽管随着诊疗技术的进步,乳腺癌的死亡率得到了实质性的降低,但它仍是女性肿瘤死亡的第二大原因,目前对乳腺癌的治疗还面临很大的挑战。长链非编码RNA(Longnon-codingRNA,LncRNA)是一类长度超过200个核苷酸的非编码RNA分子,缺乏开放的阅读框,无编码蛋白质的功能。近年来研究发现,LncRNA可能在多种恶性肿瘤的发生、发展、侵袭及转移过程中起调控作用,且目前对其与乳腺癌的关系研究较多,对LncRNA与乳腺癌相关性的研究有望为乳腺癌的诊治提供新思路。现就LncRNA在乳腺癌中的研究进展做一综述。Breast cancer is one of the most common cancer in women and its incidence continues to rise. Despite the improve- ments of diagnose and treatment, breast cancer remains the second most common cause of death from cancer in women and there is still a big challenge for its treatment. Long non-coding RNAs （LncRNAs） are a type of transcripts longer than 200 nucleotides and without pro- tein-coding capacity. Recently, many studies have shown that LncRNA play an important role in tumorigenesis, invasion and metastasis and it may provide a new method for the diagnosis and treatment of breast cancer. This review was focused on the progress on the rela- tionship between LncRNAand breast cancer.

关 键 词：长链非编码RNA 乳腺癌 研究进展 

分 类 号：R737.9[医药卫生—肿瘤]