重症急性胰腺炎中肠屏障功能障碍机制的研究进展  

Mechanism of gut barrier failure associated with severe acute pancreatitis

作　　者：徐汇[1] 曾悦[1] 

机构地区：[1]上海交通大学附属第一人民医院消化内科,上海市200080

出　　处：《世界华人消化杂志》2016年第17期2661-2666,共6页World Chinese Journal of Digestology

基　　金：上海交通大学医工交叉面上基金资助项目;No.YG2015MS29~~

摘　　要：重症急性胰腺炎(severe acute pancreatitis,SAP)常伴随肠屏障功能障碍的发生,使肠道通透性增加,继而引起细菌和内毒素移位,导致严重感染和多器官功能损害,加剧了SAP的病程.肠道微循环障碍、缺血再灌注损伤、炎症介质过度释放以及细胞凋亡、菌群失调等多种因素共同作用可能是肠屏障损伤的机制.探讨SAP中肠屏障功能障碍的发生机制,对治疗SAP具有重要的指导意义.Gut barrier failure is often present in severe acute pancreatitis （SAP）, and it increases the gut permeability, leads to translocation of bacteria or endotoxin, causes severe infection and multiple organ dysfunction syndrome, and worsens the course of the disease. The injury of gut barrier may result from the interactions among microcirculation disturbance, ischemia-reperfusion injury, excessive release of inflammatory mediators, apoptosis, flora imbalance and so on. The research on the mechanism of gut barrier failure caused by SAP is of important significance for the treatment of SAP.

关 键 词：重症急性胰腺炎 肠屏障功能障碍 发生机制 

分 类 号：R576[医药卫生—消化系统]