精神分裂症患者同型半胱氨酸及其相关影响因素的初步探讨  

Homocysteine levels in patients with schizophrenia and relation with potential factors :a preliminary

作　　者：霍贵申 张润清[1] 宋哲[1] 齐小健 

机构地区：[1]北京市昌平区中西医结合医院检验科,北京102208

出　　处：《国际精神病学杂志》2016年第3期393-395,共3页Journal Of International Psychiatry

摘　　要：目的初步探讨精神分裂症患者血清同型半胱氨酸（HCY）及其相关影响因素。方法选择2014年9月~12月北京市昌平区中西医结合医院住院病人中精神分裂症76例作为病例组,我院同期健康体检者69名作为健康对照组;收集两组的人口学特征、病例资料,采用循环酶法检测血清HCY水平。结果精神分裂症组及健康对照组的性别比例、年龄、体质指数、血糖、甘油三酯等差异均无统计学意义（P〉0.05）,精神分裂症组HCY高于健康对照组（z=-8.472,P〈0.001）,且男性HCY高于女性（P〈0.001）;logistic回归显示：精神分裂症患病风险与HCY相关（OR=2.301,P〈0.001）。结论精神分裂症患者HCY升高,且男性高于女性;HCY是影响精神分裂症患病的独立危险因素。Objective To determine the homocysteine（HCY）of patients with schizophrenia and relation with potential factors. Methods 76 inpatients and 69 healthy controls were identified at Beijing Changping Hospital of Integrated Chinese and Western Medicine from September to December,2014,respectively. Demographic data were collected and blood was analyzed for homocysteine level by circulating enzymatic method. Results There was no difference between two groups in gender proportion,age,body mass index,glucose,and triglyceride（P〉0.05）. Serum homocysteine levels of schizophrenia patients were significantly higher than the health controls（z=-8.472,P〈0.001）. And HCY in male were higher than in female（P〈0.001）. Based on binary logistic regression analysis,schizophrenia was associated with level of HCY（OR= 2.301,P〈0.001）. Conclusions Serum homocysteine were elevated in schizophrenia patients,which was higher in male than in female;HCY was independently associated with presence of schizophrenia.

关 键 词：精神分裂症 同型半胱氨酸 危险因素 性别 

分 类 号：R749.3[医药卫生—神经病学与精神病学]