阿立哌唑联合认知行为干预治疗对精神分裂症患者认知功能的影响  

The effect of aripiprazole combined with cognitive behavioral treatment on cognitive functions of schizophrenic patients

作　　者：汤耀明[1] 赵路斌[1] 徐健康[1] 王长虹 崔中芹[1] 徐冬[1] 

机构地区：[1]洛阳市精神卫生中心,洛阳471013 [2]河南省精神卫生中心

出　　处：《国际精神病学杂志》2016年第3期399-401,451,共4页Journal Of International Psychiatry

基　　金：河南省医学科技攻关项目(201303205)

摘　　要：目的探索阿立哌唑联合认知行为干预治疗对精神分裂症患者认知功能的影响。方法将86例精神分裂症患者随机分为两组,对照组单纯给予阿立哌唑治疗,研究组在阿立哌唑治疗的同时给予认知行为干预治疗。分别在入组时,3个月及6个月时进行PANSS量表评定精神状况,威斯康星卡片分类测验(WSCT)、中国修订韦氏记忆量表(WMS-RC)进行认知功能测定。结果 (1)精神症状评价结果 :对照组经过治疗3个月后各指标得分与治疗前相比差异均有统计学意义;对照组经过治疗6个月后各指标得分与3个月后相比差异均有统计学意义(P<0.05);研究组经过治疗3个月后各指标得分与治疗前相比差异均有统计学意义(P<0.05);研究组经过治疗6个月后各指标得分与3个月后相比差异均有统计学意义(P<0.05);而组间同期比较未发现有统计学意义(P>0.05)。(2)认知功能评价结果 :对照组经过治疗3个月后各指标得分与治疗前相比没有统计学意义;而经过治疗6个月后各指标得分与治疗3个月后相比差异均有统计学意义(P<0.05);研究组经过治疗3个月后各指标得分与治疗前相比差异均有统计学意义(P<0.05),与同期对照组相比各指标得分也有统计学意义(P<0.05);研究组经过治疗6个月后各指标得分与3个月后相比差异均有统计学意义(P<0.05),与同期对照组相比各指标得分也有统计学意义(P<0.05)。结论阿立哌唑合并认知行为干预比单纯阿立哌唑治疗更能改善精神分裂症患者的认知功能,对精神症状的改善没有显著优势。Objective To explore the effectiveness of aripiprazole and cognitive behavioral intervention therapy combinational therapy on the cognitive function of schizophrenia. Method 86 schizophrenia were randomly divided into the control group and the treatment group. The control group took orally with aripiprazole and the treatment group was treated with aripiprazole and cognitive behavioral intervention therapy combination. Postive and negtive symptoms scale（PANSS）,Wisconsin card sorting test（WSCT）,and China revised wechsler memory scale（WMS-RC）were used to assess the mental status and cognitive function of the patients at 3 and 6 months,resceptively after treatment.Results（1）Mental symptoms evalution ：in the control group,as compared with pre-treatment,there was significant difference after 3 months’ treatment（P〈0.05）,and as compared with 3 months’ treatment,there was significant difference after 6 months’ treatment（P〈0.05）.In the treatment group,as compared with 3 months’ treatment,there was significant difference after 6 months’ treatment（P〈0.05）. However,in the same treatment time point,there was no significant difference between the two groups（P〉0.05）.（2）Cognitive function assessment ：In the control group,as compared with pre-treatment,there was no significant difference after 3 months’ treatment（P〉0.05）. And as compared with 3 months’ treatment,there was significant difference after 6 months’ treatment（P〈0.05）.There was significant difference in the same treatment time point（P〈0.05）, in the treatment group,as compared with 3 months’ treatment,there was significant difference after 6 months’ treatment（P〈0.05）. Conclusion As compared with taking aripiprazole medicine alone,aripiprazole and cognitive behavioral intervention therapy can better improve the cognitive function of the schizophrenia patients,but has no marked advantage in the promotion of their symptoms.

关 键 词：阿立哌唑 认知行为干预 精神分裂症 

分 类 号：R749.05[医药卫生—神经病学与精神病学]