重症急性胰腺炎患者并发感染的临床特征及相关危险因素分析  

Clinical Feature and Risk Factors of Severe Acute Pancreatitis Complicated with Infection

作　　者：李晓芳[1] 李萍[2] 郭卫卫[3] 楚有良[1] 张欣[1] 

机构地区：[1]西安市中心医院消化科,陕西西安710003 [2]西安交通大学第二附属医院急诊科,陕西西安710003 [3]临汾市人民医院消化科,山西临汾041000

出　　处：《现代生物医学进展》2016年第19期3700-3702,共3页Progress in Modern Biomedicine

摘　　要：目的:分析重症急性胰腺炎(SAP)患者并发感染的临床特征及感染的相关危险因素。方法:选择我院2009年1月至2014年1月收治的SAP患者152例,所有患者入院后,根据有无发生并发感染分为感染组(n=48)和非感染组(n=105),详细记录两组临床资料,并对SAP患者并发感染的相关危险因素进行多因素回归分析。结果:152例SAP患者中有48例发生并发感染,并发感染率为31.58%,对感染组患者标本进行分析,检出病原菌58株,以肠杆菌属为主,其中阴沟肠杆菌最多,占比22.41%。经单因素及多因素回归分析显示年龄≥60岁、器官衰竭个数增加、禁食时间延长是SAP并发感染的独立危险因素(P<0.05)。结论:内源性感染是SAP患者并发感染的主要原因,且临床诊治中应针对SAP并发感染的独立危险因素,及早给予必要的干预,降低SAP患者并发感染的风险。Objective： To explore the clinical feature and risk factors of patients with severe acute pancreatitis（SAP） complicated with infection. Methods： A total of 152 patients with SAP, who were admitted to Xi＇an Central Hospital from January 2009 to January2014,were selected and divided into infection group（n=48） and non-infection group（n=105） according the status of infection. The clinical date of the two groups were recorded in detail, The risk factors of patients with SAP complicated with infection were dealt with by multivariate regression analysis. Results： Among the 152 patients with SAP, there were 48 patients complicated with infection, accounting for31.58%; the analysis of the specimens of the infection group showed that there were 58 pathogenic bacterias, among which, the enterobacter took the major part, and the enterobacter cloacae was the most,accounting for 22.41%. The univariate analysis and multivariate regression analysis showed that ≥60 years old, extended fasting time and the increase of number of organ failure were the independent risk factors of SAP complicated with infection（P〈0.05）. Conclusion： Endogenous infection is the major reason of patients with SAP complicated with infection, so necessary intervention should be given as early as possible in clinical diagnosis and treatment,regarding to its risk factors, in order to reduce the risk of occurrence of infection.

关 键 词：重症急性胰腺炎 感染 危险因素 

分 类 号：R576[医药卫生—消化系统]