术前空芯针穿刺与开放性手术活检对乳腺癌患者临床预后的影响  

Effects of Preoperative Core Needle and Open Surgical Biopsy on the Clinical Prognosis of Patients with Breast Cancer

作　　者：王妍[1] 张春侠[1] 尚永健[1] 邱衍哲 赵胤铭[1] 刘海岭[2] 

机构地区：[1]空军航空医学研究所附属医院普外科,北京100089 [2]武警北京市总队第三医院,北京100141

出　　处：《现代生物医学进展》2016年第19期3717-3719,3758,共4页Progress in Modern Biomedicine

基　　金：北京市科技计划首都临床特色应用研究专项(Z131100004013091)

摘　　要：目的:探讨术前空芯针穿刺与开放性手术活检对乳腺癌患者临床预后的影响,为乳腺癌相关临床研究提供参考。方法:选取2010年12月至2014年12月我院临床收治的早期乳腺癌患者380例为研究对象,根据诊断方法不同将患者分为术前针穿刺组(n=92)和手术活检组(n=288),观察并比较两组患者的相关临床指标及无病生存率水平进行观察和比较。结果:两组患者的年龄、淋巴结转移发生率、肿瘤分级情况、ER阳性表达率、PR阳性表达率和HER-2阳性表达率水平差异不大,且组间比较无统计学意义(P>0.05);研究组患者的肿瘤直径≥2 cm患者的比例显著高于对照组,且差异有统计学意义(P<0.01);研究组和对照组术后24个月的无病生存率分别为98.91%和99.65%,组间比较差异无统计学意(P>0.05);研究组和对照组术后36个月的无病生存率分别为95.65%和96.18%,组间比较差异无统计学意义(P>0.05)。结论:早期乳腺癌患者术前采用空芯针穿刺活检对于患者的预后没有显著影响,可以作为临床诊断患者病情的有效方法之一。Objective： To evaluate the differences of preoperative core needle and open surgical biopsy for the clinical prognosis of patients with breast cancer so as to provide a reference for the clinical researches. Methods： 380 cases with early breast cancer who were treated in our hospital from December 2010 to December 2014 were chosen, and according to the different diagnostic methods, the patients were divided into the preoperative core needle group（n=92） and the open surgery group（n=288）. The clinical indicators and the level of disease-free survival of the two groups were observed and compared. Results： There was no statistically significant about the age,the incidence of lymph node metastasis, the tumor grades, the positive expression rate of ER, PR and HER-2 between the two groups（P〈0.05）. The proportion of patients with tumor diameter ≥2 cm in the study group was significantly higher than that of the control group, and the differences were statistically significant（P〈0.01）. There was no statistically significant about the disease-free survival rates of 24 months after surgery in the study group（98.91%） and the control group（99.65 %）（P〉0.05）. There was no statistically significant about the disease-free survival rates of 36 months after surgery in the study group（95.65%） and the control group（96.18%）（P〈0.05）.Conclusion： The core needle biopsies of early breast cancer patients before surgery has not significant effect, and it can be used as an effective method of clinical diagnosis of the patient＇s condition.

关 键 词：术前空芯针穿刺 开放性手术活检 乳腺癌 临床预后 

分 类 号：R737.9[医药卫生—肿瘤]