组蛋白甲基转移酶Ezh2在肿瘤发生发展中的研究进展  

Research progress of histone methyltransferase Ezh2 in tumorigenesis

作　　者：何宗麟 郑永霞[1] 董波[1] 徐琴[1] 张成文[1] 肖燕萍[1] 

机构地区：[1]嘉兴学院医学院,嘉兴314001

出　　处：《生命的化学》2016年第3期283-287,共5页Chemistry of Life

基　　金：国家自然科学基金项目(81400854);国家大学生创新项目(201510354024)

摘　　要：肿瘤的发病率越来越高,严重威胁着人们的健康,揭示肿瘤的发病机制已是迫在眉睫。Zeste基因增强子人类同源物2(Ezh2)作为多梳抑制复合物2(polycomb repressive complex,PRC2)的催化亚基,通过调节组蛋白修饰参与染色体的表观遗传修饰。Ezh2在多种癌组织中表达升高,如前列腺癌、直肠癌、卵巢癌等,与肿瘤的发生发展密切相关。本文就Ezh2基因在肿瘤发生发展中的作用及其机制做一综述。The incidence of cancer is increasing and have posed serious threat to the people＇s health. Therefore, it is urgent to reveal the pathogenesis of tumor. Zeste enhancer human homologue gene 2（Ezh2）, the catalytic subunit of polycomb repressive complex（PRC2）, adjust the epigenetic modification of histone modifications in chromosomes, and Ezh2 is usually overexpressed in a variety of cancers, such as prostate cancer, colorectal cancer, ovarian cancer, etc. In this paper, we have summarized the research progress of its role and mechanism in the development of tumor.

关 键 词：EZH2基因 肿瘤 表观遗传 研究进展 

分 类 号：R730.2[医药卫生—肿瘤]