亚洲人群环氧化酶-2基因多态性与胃癌关联性的系统性回顾与Meta分析  

Meta-analysis on the relationship between cyclooxygenase-2 gene polymorphism and gastric cancer in Asian population

作　　者：文静[1] 任孟军[1] 谭伟[1] 

机构地区：[1]重庆市第三人民医院消化内科,重庆400014

出　　处：《重庆医科大学学报》2016年第6期609-613,共5页Journal of Chongqing Medical University

摘　　要：目的:综合评价亚洲人群环氧化酶-2(cyclooxygenase-2,COX-2)基因多态性与胃癌的关系。方法:以中国生物医学文献光盘数据库(CBMdisc)、CNKI、万方和维普电子数据库为中文文献信息来源,Pub Med、Science Direct、Google学术和Scopus电子数据库为英文文献信息来源,采用主题词和自由词相结合的检索方式,检索2000年1月至2015年2月期间,国内外发表的关于COX-2基因多态性与胃癌研究的相关文献。应用Rev Man 5.0软件对符合条件的研究结果进行Meta分析。结果:共纳入13篇符合纳入标准的文献,包括8篇英文文献和5篇中文文献。数据合并结果显示COX-2-765G>C基因多态性CC基因型、GC基因型与胃癌有明显关联(P<0.05),而8473T>C、-1195G>A和587G>A基因多态性各基因型与胃癌无显著关系。结论:COX-2-765G>C基因多态性与胃癌发病有显著关联,可能是胃癌发病的危险因子;而8473T>C、-1195G>A和587G>A可能并不是胃癌的易感因素。Objective：To assess the association of cyclooxygenase-2（COX-2）gene polymorphism with gastric cancer by Meta-analysis.Methods：Literatures on the relationship between COX-2 gene polymorphism and gastric cancer from January 2000 to February 2015 were searched in CBMdisc,Wanfang,VIP and CNKI,Pub Med,Science Direct,Google Scholar and Scopus. Thirteen articles were enrolled,including 8 English articles and 5 Chinese articles. Software of Rev Man 5.0 was used. Results：The results show a significant association between COX-2 gene polymorphism-765G〉C with gastric cancer,including the allele contrast model,homozygote model and heterozygotes genotypes;however no association was found between COX-2 gene polymorphism 8473 T〉 C,-1195 G 〉A,587 G A and gastric cancer. Conclusion：COX-2 gene polymorphism-765G〉C may be the risk of gastric cancer as an independent risk factor,but not the polymorphism 8473T〉C,-1195G〉A,587G〉A.

关 键 词：胃癌 环氧化酶-2 基因多态性 META分析 

分 类 号：R735.2[医药卫生—肿瘤]