肥胖相关非酒精性脂肪性肝病防治的新靶点：短链脂肪酸及其受体信号通路的保护作用  

New targets for prevention and treatment of obesity related NAFLD:short-chain fatty acids and short-chain fatty acid receptors signaling pathways

作　　者：梁荫基[1] 林琛莅[2] 王少娜[3] 张玉佩[4] 韩莉[5] 王观龙[4] 李媛媛[4] 邓远军[4] 何毅芳 何亲羽 蔡小双[1] 杨钦河[4] 

机构地区：[1]暨南大学医学院护理学系,广州510632 [2]暨南大学医学院病理学系,广州510632 [3]汕头市澄海区人民医院妇产科,汕头515800 [4]暨南大学医学院中医学系,广州510632 [5]暨南大学附属第一医院中医科,广州510632

出　　处：《重庆医科大学学报》2016年第6期628-631,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:81573844);广东省自然科学基金资助项目(编号:2014A030313365);暨南大学医学院护理科研培育基金资助项目(编号:5690014);暨南大学大学生创新创业训练计划资助项目(编号:CX15184)

摘　　要：近年来,全球肥胖相关非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的发病率和患病率不断上升,但其发病机制尚未完全清楚,临床仍缺乏有效防治手段。目前普遍认为肥胖相关NAFLD是一个多系统疾病,最近研究也证实肠道菌群及其代谢产物在肥胖相关NAFLD发病中起重要作用。作为肠道菌群主要代谢产物短链脂肪酸(short-chain fatty acids,SCFAs),可能通过多种途径(肠道、脂肪组织、肝脏)介导机体炎症反应,直接或间接影响肥胖相关NAFLD的发生发展。因此,从SCFAs及其受体信号通路的角度,探讨肥胖相关NAFLD治疗的药物靶点,将是防治NAFLD的新途径。In recent years,the incidence and prevalence of nonalcoholic fatty liver disease（NAFLD）has been increasing all over the world and the pathogenesis of NAFLD is unclear. But effective methods of prevention and treatment of NAFLD are insufficient. Now it is widely considered that obesity related NAFLD is a multisystem disease. Recent studies have confirmed that the intestinal flora and their metabolites play an important role in the pathogenesis of obesity related NAFLD. As the main metabolites of intestinal flora,short-chain fatty acids（SCFAs）may mediate the systematic inflammatory response,and directly or indirectly affect the incidence and development of obesity related NAFLD through a variety of ways（intestinal,adipose tissue and liver）. Therefore,study on SCFAs and short-chain fatty acid receptors signaling pathways will provide new targets for the prevention and treatment of obesity related NAFLD.

关 键 词：非酒精性脂肪性肝病 肥胖 短链脂肪酸 短链脂肪酸受体 

分 类 号：R575.5[医药卫生—消化系统]