乳腺癌冠状面汇聚征和生物学行为指标间的相关性研究  

Correlation between retraction phenomenon on the coronal planes and biological behaviors of breast cancer

作　　者：郑逢洋 黄备建[1] 严丽霞[1] 王希[1] 阳军[1] 沈海云[1] 袁伟[2] 

机构地区：[1]复旦大学附属中山医院超声科复旦大学超声医学与工程研究所,上海200032 [2]复旦大学附属中山医院病理科,上海200032

出　　处：《中华超声影像学杂志》2016年第6期496-501,共6页Chinese Journal of Ultrasonography

基　　金：基金项目：国家自然科学基金项目（81371577）

摘　　要：目的：探讨自动乳腺全容积扫描（automated breast volume scanner,ABVS）冠状面汇聚征与乳腺癌生物学行为之间的相关性。方法选取术前行 ABVS 检查并经病理证实的288例乳腺癌患者,共293个病灶。回顾性观察病灶 ABVS 冠状面是否出现汇聚征。通过单变量逻辑回归分析比较汇聚征与乳腺癌激素受体（hormone receptor,HR）、人表皮生长因子受体2（human epidermal growth factor receptor 2,HER-2）、Ki-67、分子分型、组织学类型、病理分级、淋巴结转移情况、病灶大小及患者年龄的相关性。差异有统计学意义的变量进一步纳入多变量逻辑回归分析,选出冠状面出现汇聚征的独立危险因素。结果通过单变量逻辑回归分析得出 Luminal A 型[优势比（odds radio,OR）=8395, P 〈0001]、HR 阳性（OR=4876,P 〈0001）、HER-2阴性（OR=4407,P 〈0001）、Ki-67低表达（OR=3716,P 〈0001）、低级别（OR =3574,P 〈0001）、淋巴结转移（OR =2053,P =0004）及较小病灶（OR=1762,P =0033）是冠状面出现汇聚征的危险因素,而组织学类型（P =0318）和患者年龄（P =0612）与汇聚征无明显相关性。通过多变量逻辑回归分析得出 Luminal A 型（OR=9877,P 〈0001）、低级别（OR=3573,P 〈0001）及淋巴结转移（OR=2730,P =0004）是冠状面出现汇聚征的独立危险因素,其中 Luminal A 型是最强的独立危险因素。结论 ABVS 冠状面汇聚征与 Luminal A 型乳腺癌密切相关,可能是低侵袭性乳腺癌的一种影像表现。Objective To investigate the correlation between retraction phenomenon on the coronal planes obtained by an automated breast volume scanner ABVS and biological behaviors of breast cancer Methods Two hundred and eighty-eight female patients with 293 pathologically proven breast cancers were included in this study All of them underwent ABVS examinations before surgery Retraction phenomenon on the coronal planes was evaluated retrospectively Correlation between retraction phenomenon and hormone receptor HR human epidermal growth factor receptor 2 HER-2 Ki-67 molecular subtypes histologic type histologic grade lymph node status lesion size and patient age were evaluated by univariate logistic regression analysis Above significant variables were then enrolled in multivariate logistic regression analysis to select independent risk factors for retraction phenomenon Results By univariate logistic regression analysis Luminal A subtype odds radio OR =8 395 P 〈0 001 HR positive OR=4 876 P 〈0 001 HER-2 negative OR = 4 407 P 〈 0 001 lower expression of Ki-67 OR = 3 716 P 〈0 001 lower grade OR=3 574 P 〈0 001 lymph node invasion OR=2 053 P =0 004 and smaller lesion OR=1 762 P =0 033 were risk factors for retraction phenomenon while histologic type P =0 3 1 8 and patient age P = 0 612 were not By multivariate logistic regression analysis Luminal A subtype OR=9 877 P 〈0 001 lower grade OR=3 573 P 〈0 001 and lymph node invasion OR=2 730 P = 0 004 were independent risk factors for retraction phenomenon among which Luminal A subtype was the strongest one Conclusions Retraction phenomenon on the coronal planes obtained by ABVS is closely related with Luminal A subtype and may be an imaging feature of less aggressive behaviors of breast cancer.

关 键 词：超声检查 三维 乳腺肿瘤 汇聚征 自动乳腺全容积扫描 

分 类 号：R737.9[医药卫生—肿瘤]