酸敏感离子通道3及其基因敲除小鼠特性的研究进展  

Research Progress of Acid- sensing Ion Channel 3 and Its Knockout Mice

作　　者：徐坤[1] 王巍[1] 

机构地区：[1]辽宁中医药大学针灸推拿学院,辽宁沈阳110847

出　　处：《中华中医药学刊》2016年第7期1653-1655,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB518503)

摘　　要：酸敏感离子通道3(acid-sensing ion channels 3,ASIC3)是对p H值改变最敏感的酸受体。在对ASIC3及其基因敲除小鼠(ASIC3-/-小鼠)的研究中发现,ASIC3参与痛觉、酸味觉、感受伤害性刺激、心肌缺血等多种生理和病理过程,并发挥重要作用。这些成果为在分子水平研究针刺治疗疾病的机制提供条件和基础。Acid- sensitive ion channel 3 is most sensitive to changes in p H of an acid acceptor. The research on ASIC3 and its knockout mice has found that ASIC3 participates in a variety of physiological and pathological processes such as pain,acid taste,feeling nociceptive stimulation,myocardial ischemia and so on,plays an important role. These findings provide the basis and conditions for the studies of acupuncture treatment which mechanism is at the molecular level.

关 键 词：酸敏感离子通道3 基因敲除 小鼠 

分 类 号：R-332[医药卫生]