早发精神分裂症静息态脑功能低频振幅研究  

Resting state fMRI study of amplitude of low-frequency fluctuation in early onset schizophrenia

作　　者：熊燕兵[1] 任燕 崔晓红 徐文悦[1] 孙晓丽[1] 杨红 

机构地区：[1]山西医科大学,太原030001 [2]山西大医院精神卫生科

出　　处：《中国神经精神疾病杂志》2016年第5期272-276,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：山西省卫生厅科研课题(编号:201301047)

摘　　要：目的通过静息态功能磁共振研究早发未用药精神分裂症患者局部脑功能低频振幅(amplitude of low-frequency fluctuation,ALFF)的变化,探讨其静息态下功能异常的脑区。方法收集20例早发未用药精神分裂症患者与20名性别、年龄、受教育年限相匹配的正常对照,分别对其进行全脑静息态功能磁共振扫描,计算ALFF值。结果与对照组相比,患者组左侧额上回、左侧楔前叶、左侧扣带回、左侧枕叶、左侧海马旁回、左侧距状沟ALFF值增高(P<0.05,Alpha Sim校正),右侧颞上回和右侧小脑后叶ALFF值降低(P<0.05,Alpha Sim校正)。结论早发精神分裂症患者在静息态下有多处脑区ALFF值改变,提示其在静息态下存在脑功能异常。Objective To investigate brain function alteration in early onset schizophrenia by amplitude of low-frequency fluctuation（ALFF） based on resting-state functional MRI（f MRI）.MethodTwenty patients with early onset schizophrenia and 20 sex, age, education years matched healthy controls underwent resting-state functional MRI. The difference in ALFF was compared between patients and controls.ResultCompared with control group, the ALFF values in patient group increased in the left frontal gyrus, precuneus, cingulate cortex, occipital lobe, parahippocampal gyrus and calcarine（P〈0.05, Alpha Sim revised）, while decreased in the right superior temporal lobe and the posterior lobe of cerebellum（P〈0.05, Alpha Sim revised）.ConclusionThere are abnormal ALFF in multiple regions in early onset schizophrenia, suggesting that early onset schizophrenia may have altered in resting-state brain activity.

关 键 词：早发精神分裂症 静息态功能磁共振成像 低频振幅 

分 类 号：R749.3[医药卫生—神经病学与精神病学]