晚期非小细胞肺癌恶病质患者血清IL-1和GH/IGF-1水平的变化及意义  

Changes and significance of serum IL-1 and GH/IGF-1 levels in advanced non-small cell lung cancer patients with cachexia

作　　者：何婧[1] 缪捷飞[1] 钱俐[1] 

机构地区：[1]南通大学附属医院肿瘤化疗科,南通226001

出　　处：《南通大学学报（医学版）》2016年第3期196-198,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:观察晚期非小细胞肺癌(non-small cell lu ng cancer,NSCLC)恶病质患者血清白细胞介素-1(interleukin-1,IL-1)、生长激素(growth hormone,GH)/胰岛素样生长因子-1(insulin-like growth factor 1,IGF-1)水平的变化及其意义。方法:选取41例晚期NSCLC恶病质患者为恶病质组;42例晚期NSCLC非恶病质患者为非恶病质组;另选取24例健康就诊者为对照组。检测所有入选者的营养参数包括体质量指数(body mass index,BMI)、上臂中部臂围(midupper arm circumference,MAC)及血清白蛋白(albumin,ALB);并用酶联免疫吸附法检测入选者血清IL-1、GH和IGF-1的含量。结果:(1)与对照组相比,非恶病质组BMI、MAC及ALB的差异无统计学意义(P>0.05),恶病质组BMI、MAC及ALB均明显降低(P<0.05);与非恶病质组相比,恶病质组BMI、MAC及ALB均明显降低(P<0.05)。(2)与对照组相比,非恶病质组及恶病质组血清IL-1、GH及IGH表达均明显增加(P<0.05),恶病质组GH/IGF-1升高(P<0.05);与非恶病质组相比,恶病质组血清IL-1及GH表达增加(P<0.05),而IGF-1表达降低(P<0.05),GH/IGF-1升高(P<0.05)。结论:晚期NSCLC恶病质患者营养状况明显恶化,IL-1和GH/IGF-1的变化可能介导了晚期NSCLC患者恶病质的发生。Objective： To study the expression of serum interleukin-1（IL-1） and growth hormone/insulin-like growth factor 1（GH/IGF-1） levels in advanced non-small cell lung cancer（NSCLC） patients with cachexia and its significance. Methods： 41 cases of NSCLC patients with cachexia were used as the cachexia group; 42 cases of NSCLC patients without cachexia were used as the non-cachexia group; and 24 healthy people were taken as normal controls. All the subjects were tested the nutrition index such as： body mass index（BMI）, mid-upper arm circumference（MAC） and serum albumin（ALB）; and the serum levels of IL-1, GH and IGF-1 were detected by enzyme-linked immunoabsorbent assay（ELISA）. Results：（1）Compared with control group and non-cachexia group, the nutrition index： BMI, MAC and ALB were significantly decreased in the cathexia group（P〈0.05）.（2）Compared with control group, the expression of IL-1, GH and IGF-1 in non-cachexia group and cathexia group were all increased（P〈0.05）,GH/IGF-1 in cathexia group was increased（P〈0.05）. Compared with non-cachexia group,the expression of IL-1, GH in cachexia group were increased（P〈0.05）, while the expression of IGF-1 was decreased（P〈0.05）,GH/IGF-1 was increased（P〈0.05）. Conclusion： Nutrition status decreases in NSCLC patients with cachexia. The changes of serum IL-1 and GH/IGF-1 levels may play a role in the occurrence of cachexia in NSCLC patients.

关 键 词：晚期非小细胞肺癌 恶病质 白细胞介素-1 生长激素 胰岛素样生长因子-1 

分 类 号：R734[医药卫生—肿瘤]