细胞因子在葡萄膜炎并发性白内障中的作用机制  

The role of cytokines in complicated cataract caused by uveitis

作　　者：张英蕾[1] 竺向佳[1] 卢奕[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《国际眼科纵览》2016年第3期178-182,共5页International Review of Ophthalmology

摘　　要：CD4T细胞相关细胞因子、血管内皮生长因子（ vascular endothelial growth factor,VEGF）、促炎细胞因子等在炎症中的作用已得到证实，这些因子在活动期葡萄膜炎高水平表达。非感染性葡萄膜炎并发性白内障由于炎症反复，术后并发症发生率较高。其发生机制由多种免疫细胞及细胞因子共同参与，但具体作用仍不清楚。近年来，这些细胞因子在非感染性葡萄膜炎并发性白内障中的表达水平以及具体作用逐渐被了解，而针对这些细胞因子的药物也用于临床，但其有效性有待进一步观察。The role of cytokines （ CD4 ＋ T-associated cytokines, VEGF, pro-inflammatory cytokine, etc） in inflammation has been demonstrated, and a high-level expression has been showed in active period. Postoperative complications of complicated cataract in patients with non-infectious uveitis are frequent and se-vere because of the recurrent inflammation. Multiple cytokines are involved in the pathogenesis of complica- tions, but the specific mechanism is still unclear. In recent years, more studies about cytokines expression and its function have been performed. In addition, the efficacy of the treatments specific to cytokines have been published and satisfactory outcomes have been achieved.

关 键 词：非感染性葡萄膜炎 CD4+T细胞 血管内皮生长因子 促炎细胞因子 

分 类 号：R776.1[医药卫生—眼科]