卵巢幼年型颗粒细胞瘤临床病理观察  

Clinicopathological observations of ovarian juvenile granulosa cell tumor

作　　者：郭晓霞[1] 许春伟[2] 张立英[3] 

机构地区：[1]北京市怀柔区妇幼保健院病理科,北京101400 [2]军事医学科学院附属医院病理科,北京100071 [3]中国人民解放军北京军区总医院病理科,北京100700

出　　处：《临床与病理杂志》2016年第6期868-873,共6页Journal of Clinical and Pathological Research

摘　　要：目的：探讨幼年型颗粒细胞瘤的临床病理学特点及诊断要点。方法：对2例幼年型颗粒细胞瘤进行临床资料、病理形态学及免疫组织化学观察,并结合文献对其诊断及鉴别诊断进行探讨。结果： 2例镜下可见肿瘤细胞卵圆形或短梭形,胞质淡染,部分空泡状,成巢分布,呈多结节样生长,与周围卵巢组织有明显分界,局部区域有黏液样变性,血管丰富,部分细胞生长活跃,核分裂易见（5~7个/HPF）,核沟不明显,未见Call-Exner小体。免疫组织化学染色结果：ER、PR、Vimentin和α-inhibit阳性,Ki-67增殖指数25%~40%不等。结论：卵巢幼年型颗粒细胞瘤是一种少见肿瘤,易与其他肿瘤混淆导致误诊,其临床病理特点应引起临床医师重视。Objective： To explore the characteristics of clinicopathology and diagnostic criteria of ovarian juvenile granulosa cell tumor. Methods： The clinical data, histopathologic observation and immunohistochemical staining were studied in two cases of juvenile granulosa cell tumor. Results： Microscopic examination showed two cases of tumor was composed of ovoid cells or fusiform cells with cytoplasmic light dye, part of vacuolated with a nest. The multiple nodular growth and myxoid background with the surrounding ovary tissues which had a clear boundary were present. Blood vessels were rich with part of the cell growth. Mitosis often appears（5~7/HPF）, nuclear groove was not obvious, and it did not see Call-Exner corpuscle. Immunohistochemically, revealed positivity for ER, PR, Vimentin and α-inhibit, and Ki-67 index ranges from 25% to 40%. Conclusion： Ovarian juvenile granulosa cell tumor is a rare tumor, and is easily confused with other tumor, leading to misdiagnosis. Clinicians should pay more attention on its clinicopathological characteristics.

关 键 词：卵巢肿瘤 颗粒细胞瘤 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]