Tau蛋白的研究进展  

The research progress of Tau protein

作　　者：张鸿日[1] 彭静华[1] 周洪龙 徐如祥 

机构地区：[1]河南科技大学第一附属医院神经外科,洛阳471003 [2]北京军区神经外科研究所,北京100700

出　　处：《中华神经创伤外科电子杂志》2016年第2期108-111,共4页Chinese Journal Of Neurotraumatic Surgery：Electronic Edition

摘　　要：Tau蛋白是微管相关蛋白,不仅广泛表达于中枢和外周神经系统,也存在于肺、肾、睾丸等组织中。在中枢神经系统中Tau蛋白主要分布在神经元轴突,参与微管的装配并维持微管的稳定。Tau蛋白的异常堆积被认为是老年痴呆症的神经病理学标志。本文就Tau蛋白的功能和相关疾病做了详细综述。Tau protein is microtubule associated protein, not only express the central and peripheral nervous system, but also present in the lung, kidney and testis tissue. Tau protein in the central nervous system are mainly distributed in neuronal axons, participate in the assembly of microtubules and maintain the stability of microtubules. Abnormal accumulation of Tau protein is considered to be neuropathology sign of Alzheimer’s disease. In this paper, the function of the Tau protein made detailed reviews and related diseases.

关 键 词：TAU蛋白 阿尔兹海默病 神经退行性变 

分 类 号：R741[医药卫生—神经病学与精神病学]