空腹血糖水平与进展性缺血性脑卒中的相关性研究  

Correlation between fasting blood glucose level and progressive ischemic stroke

作　　者：陈月富 苏斌儒[2] 罗成宏[2] 陆伟恒[2] 

机构地区：[1]湖南医药学院护理学院,怀化418000 [2]南方医科大学附属东莞石龙人民医院神经内科

出　　处：《中华老年心脑血管病杂志》2016年第7期719-721,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：东莞市科技计划项目(20101051502402)

摘　　要：目的探讨空腹血糖水平与进展性缺血性脑卒中的相关性。方法选择在南方医科大学附属石龙人民医院接受治疗的急性缺血性脑卒中患者428例,其中男性310例,女性118例,平均年龄(65.26±11.12)岁。根据发病后6h^1周美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分将患者分为进展性脑卒中组60例和非进展性脑卒中组368例。收集所有患者的基本临床资料,并进行TC、TG、HDL、LDL、空腹血糖、糖化血红蛋白、纤维蛋白原、同型半胱氨酸水平检查。结果进展性脑卒中组年龄[(68.77±11.99)岁vs(63.53±11.10)岁,P=0.001]、高脂血症(65.0%vs 51.1%,P=0.047)、空腹血糖[(7.78±4.42)mmol/L vs(6.61±2.60)mmol/L,P=0.048]均显著高于非进展性脑卒中组。多因素logistic回归分析表明,年龄(OR=1.070,95%CI:1.033~1.108,P=0.000)及空腹血糖(OR=1.369,95%CI:1.173~1.598,P=0.000)是进展性脑卒中的独立危险因素。结论在急性缺血性脑卒中患者的治疗中,应密切监控患者的空腹血糖水平,良好的血糖水平有可能减少进展性脑卒中的发生。Objective To study the correlation between fasting blood glucose level and progressive ischemic stroke.Methods Four hundred and twenty-eight acute ischemic stroke patients（310males and 118females）aged 65.26±11.12 years were divided into progressive ischemic stroke group（n=60）and non-progressive ischemic stroke group（n=368）according to their NIHSS score.Their serum TC,TG,HDL,LDL,fasting blood glucose,HbA1 c,fibrinogen and homocysteine levels were measured.Results The age was significantly older,the incidence of hyperlipidemia and the fasting blood glucose level were significantly higher in progressive ischemic stroke group than in non-progressive ischemic stroke group（68.77±11.99 years vs 63.53±11.10 years,P=0.001;65.0%vs 51.1%,P=0.047;7.78±4.42mmol/L vs 6.61±2.60mmol/L,P=0.048）.Multivariate logistic regression analysis showed that age and fasting blood glucose level were the independent risk factors for progressive ischemic stroke（OR=1.070,95%CI：1.033-1.108,P=0.000;OR=1.369,95%CI：1.173-1.598,P=0.000）.Conclusion Fasting blood glucose level should be controlled in treatment of acute ischemic stroke in order to reduce the incidence of progressive ischemic stroke.

关 键 词：血糖 卒中 动脉粥样硬化 高脂血症 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]