探讨GNB3基因C825T多态性与缺血性脑卒中的关系  

Investigate the Relationship Between GNB3 Gene C825T Polymorphism and Ischemic Stroke

作　　者：冯涛[1] 徐秀芝[1] 杨勇[1] 黄国峰[1] 

机构地区：[1]黑龙江省医院神经内科,黑龙江哈尔滨150001

出　　处：《中国继续医学教育》2016年第14期67-68,共2页China Continuing Medical Education

基　　金：哈尔滨市科技局基金项目(编号:2013RFXYJ047)

摘　　要：目的探讨缺血性脑卒中患者GNB3基因C825T多态性与疾病发生的相关性。方法收集我院治疗的缺血性脑卒中患者100例为脑卒中组,再收集100名健康人作为正常组,抽取所有研究对象的外周血,对基因型进行统计分析。结果脑卒中组基因型分布频率CC型31.03%,正常组基因型分布频率CC型34.53%,两组差异无统计学意义(P>0.05)。缺血性脑卒中的等位基因C825的出现率为55.2%,正常组等位基因C825的出现率为56.1%。缺血性脑卒中的等位基因825T的出现率为44.6%,正常组等位基因825T的出现率为42.9%,两组等位基因出现差异不具有统计学意义(P>0.05)。结论 GNB3基因C825T多态性与缺血性脑卒中的发生与进展的相关性不大,但是不排除由于研究对象较少等影响研究结果。Objective To investigate the relationship between C825 T gene GNB3 polymorphism and disease occurrence in patients with ischemic stroke. Methods 100 cases with ischemic stroke who were treated in our hospital were collected as ischemic stroke group, and 100 healthy persons were collected as control group. The peripheral blood of all subjects were collected and analyzed. Results The distribution frequency of CC genotype in ischemic stroke group was 31.03%, and the genotype distribution frequency of CC genotype in the normal group was 34.53%, the difference between the two groups was not significant（P〉0.05）. Ischemic stroke allele C825 rate was 55.2%, the appearance of the normal allele C825 was 56.1%. Ischemic stroke appears 825 T allele was 44.6%, the appearance of the normal allele 825 T was 42.9%, there were no significant difference（P〉0.05）.Conclusion There is little correlation between GNB3 gene C825 T polymorphism and the occurrence and progression of ischemic stroke, but it does not rule out the research results.

关 键 词：GNB3基因 多态性 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]