原癌基因Ras诱导的衰老与逃逸衰老机制的研究进展  

Current Advances of Ras Induced Senescence and The Bypass Mechanism

作　　者：郭雨声 张如意[1] 贾舒婷[1] 罗瑛[1] 

机构地区：[1]昆明理工大学医学院衰老与肿瘤分子遗传学实验室,昆明650500

出　　处：《生物化学与生物物理进展》2016年第7期652-660,共9页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(31170735;81460457)~~

摘　　要：在体内和细胞内由癌基因诱导的衰老(oncogene-induced senescence,OIS)是一种重要的癌症抑制机制.原癌基因Ras是人类癌症中最易突变的癌基因之一,尽管有OIS的存在,但是Ras诱导的恶性转化还是时有发生,这提示Ras基因可能存在着能够逃逸衰老的机制.本文以Ras的信号通路为线索,着重阐述和总结了Ras是如何激活一些OIS过程中的关键分子从而诱导衰老的,并且描述了几种Ras通过抑制OIS的关键因子从而逃逸衰老的机制.Oncogene induced cell senescence is an important tumor suppressor mechanism in vivo and in vitro.Ras is one of the most frequently mutant oncogene in human cancers.However,Ras induced cell transformation and malignization happened sometimes even under the supervision of OIS,which implicated Ras may obtained some pathways to bypass OIS.This article took Ras signal pathway as the main clue,to summarize the key molecules involved in OIS progression induced by Ras and some potential OIS overcome mechanism of Ras.

关 键 词：RAS P53 RB OIS MAPK 原癌基因诱导的衰老 

分 类 号：Q7[生物学—分子生物学] Q5