Livin和PTEN在卵巢子宫内膜异位症癌变组织中的表达和相关性研究  

Expressions of Livin and PTEN in Cancerous Tissues of Ovary Endometriosis

作　　者：刘星娅 王红静[1] 徐盼[1] 陈静[1] 潘海英[1] 刘亚[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041

出　　处：《四川大学学报（医学版）》2016年第4期512-515,共4页Journal of Sichuan University(Medical Sciences)

基　　金：四川省科技厅项目(No.2012SZ0022)资助

摘　　要：目的探讨Livin、PTEN蛋白在卵巢子宫内膜异位症癌变组织中的表达及其相关性。方法采用免疫组织化学EliVision法检测19例卵巢子宫内膜异位症癌变组织、30例卵巢子宫内膜异位症组织和30例卵巢良性肿瘤组织中Livin及PTEN蛋白的表达。结果Livin在卵巢子宫内膜异位症癌变组织中的阳性表达率(68%)高于卵巢子宫内膜异位症(36%)和卵巢良性肿瘤(13%)(P<0.05),Livin阳性表达率与卵巢子宫内膜异位症癌变患者年龄、临床分期、分级、组织学类型和淋巴结转移均无关(P>0.05);PTEN在卵巢子宫内膜异位症癌变组织中的阳性表达率(16%)低于卵巢子宫内膜异位症(65%)和卵巢良性肿瘤(80%)(P<0.01),PTEN阳性表达率与卵巢子宫内膜异位症癌变患者年龄、临床分期、分级、组织学类型和淋巴结转移均无关(P>0.05);卵巢子宫内膜异位症癌变组织中Livin与PTEN表达呈负相关(r=-0.559,P=0.001)。结论 Livin表达上调和PTEN表达缺失与卵巢子宫内膜异位症癌变的发生、发展有关。Objective To investigate the expressions of Livin and phosphate and tension homology deleted on chromsome ten（PTEN）protein in the cancerous tissues of ovary endometriosis.Methods Immunohistochemistry EliVision was used to examine the expressions of Livin and PETN protein in 19 samples of ovary endometriosis cancerous tissues,30 samples of ovary endometriosis tissues and 30 samples of ovarian benign tumor tissues.Results The positive expression rate of Livin in ovary endometriosis cancerous tissues（68%）was obviously higher than that in ovary endometriosis tissues（36%）and benign tumor tissues（13%）（P〈0.05）.The positive expression rate of PTEN in ovary endometriosis cancerous tissues（16%）was obviously lower than that in ovary endometriosis tissues（65%）and benign tumor tissues（80%）（P〈0.01）.There was no correlations between positive expressions of Livin and age,clinical stage,grading,histological type and lymphatic metastasis of ovary endometriosis cancer（P〉0.05）,the same result was also found for PTEN.Livin and PTEN expression presented an obviously negative correlation in ovary endometriosis cancer（r=-0.559,P=0.001）.Conclusion Up-regulation of Livin expression and down-regulation of PTEN may be involved in the occurrence and development of ovary endometriosis cancerization.

关 键 词：卵巢子宫内膜内异症癌变 凋亡抑制基因 LIVIN PTEN 相关性 免疫组织化学 

分 类 号：R737.3[医药卫生—肿瘤]