肝细胞癌相关抗原特异性T淋巴细胞的研究进展  

Immunological characteristics of tumor antigen specific T cells and their possible mechanisms in hepatocellular carcinoma

作　　者：侯玉丽[1] 张永宏[2] 赵艳[1] 

机构地区：[1]首都医科大学附属北京佑安医院临床检验中心,北京100069 [2]首都医科大学附属北京佑安医院生物信息中心,北京100069

出　　处：《临床肝胆病杂志》2016年第6期1220-1224,共5页Journal of Clinical Hepatology

基　　金：首都医科大学基础临床合作基金(1150170804)

摘　　要：肝细胞癌(HCC)是世界范围的一个主要卫生问题,其发病率逐年上升,且早期诊断率较低,晚期HCC的生存率低,因此HCC的诊断和治疗引起了广泛关注,其中肿瘤特异性淋巴细胞免疫在其中发挥了重要作用。阐述了甲胎蛋白、磷脂酰肌醇蛋白多糖3、NY-ESO-1、SSX-2、黑色素抗原基因A、端粒酶反转录酶和肝癌相关抗原-519/靶蛋白xklp-2等HCC相关抗原特异性T淋巴细胞免疫特征,并从调节性T淋巴细胞、髓源性抑制细胞、抗原的递呈和处理、抑制性受体和CD4+T淋巴细胞方面分析了影响抗原特异性T淋巴细胞免疫的可能机制。通过研究HCC相关抗原特异性T淋巴细胞的免疫反应,从而对HCC的免疫治疗提供新的方向和治疗靶点。Hepatocellular carcinoma （HCC） is a major health problem around the world and its morbidity is increasing year by year. HCC has a low rate of early diagnosis and advanced HCC has a low survival rate. Therefore, the diagnosis and treatment of HCC has attracted great attention, and tumor specific T cell immunity plays an important role in it. This article describes the immunological characteristics of seven HCC - associated antigen specific T cells, i. e. , alpha fetal protein, phosphatidylinositol proteoglycan - 3, NY - ESO - 1 , SSX - 2, mela- noma antigen gene A, telomerase reverse transcriptase, and HCC -associated antigen -519/target protein xklp -2, and analyzes the possi- ble mechanisms which affect antigen specific T cell immunity from the aspects of regulatory T cells, myeloid - derived suppressor cells, anti- gen presenting and processing, inhibitory receptors, and CD4 ＋ T cells.

关 键 词：癌 肝细胞 抗原 肿瘤 T淋巴细胞 综述 

分 类 号：R735.7[医药卫生—肿瘤]