降钙素原和C反应蛋白与急性脑梗死患者短期预后的相关性研究  

Correlation between serum PCT,CRP and 90 d brain function recovery in patients with acute cerebral infarction

作　　者：唐小勇[1] 钟万芬[1] 尚芙蓉[1] 

机构地区：[1]湖北省襄阳市中心医院检验科,441021

出　　处：《检验医学与临床》2016年第13期1803-1805,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨急性脑梗死(ACI)患者血清降钙素原(PCT)、C反应蛋白(CRP)水平与短期脑功能恢复的相关性。方法以该院2013年1月至2014年12月收治的100例ACI患者及50例同期体检健康者为研究对象,分析入院时PCT、CRP、美国国立卫生研究院脑卒中量表(NIHSS)评分等与90d临床预后的相关性。结果不良转归患者最高NIHSS高于良好转归患者(P<0.05)。不良转归患者入院PCT水平高于健康者和良好转归患者(P<0.05)。受试者工作特征曲线分析显示,最高NIHSS对90d预后的预测价值较高,曲线下面积(AUC)为0.733,灵敏度为75.5%,特异度为77.2%;入院时PCT的AUC为0.841,灵敏度为87.0%,特异度为82.9%。最高NIHSS与入院时PCT呈正相关,而入院时PCT和NIHSS与90d改良Ranking量表(mRS)评分呈负相关(P<0.05)。最高NIHSS(>22.3分)和入院时PCT(>2.5ng/mL)是90d预后不良的独立危险因素。结论ACI发病后早期血清PCT水平是评价患者90d临床预后的潜在预测因子。Objective To evaluate the correlation between procalcitonin （PCT ） ,C‐reactive protein （CRP） and 90 d brain func‐tion recovery in patients with acute cerebral infarction （ACI） .Methods A total of 100 patients with ACI and 50 healthy subjects were enrolled .The levels and correlation of PCT ,National Institute of Health stroke scale （NIHSS） scores ,CRP and 90 d brain function recovery were analyzed .Results The levels of NIHSS scores in unfavorable group were higher than favorable group （P〈0 .05） .The levels of PCT in unfavorable group were higher than favorable group and control group （P〈0 .05） .Receiver operating character（ROC） curve analysis showed that the area under curve （AUC ） ,sensitivity and specificity of top NIHSS was 0 .733 , 75 .5% and 77 .2% ,and those of PCT were 0 .841 ,87 .0% he 82 .9% .Top NIHSS was positively associated with PCT ,and both top NIHSS and PCT were negatively related with 90 d modified Rankin Scale （mRS） .Conclusion Serum PCT in early stage could be a potential prognosis factor for 90 d brain function recovery in patients with ACI .

关 键 词：急性脑梗死 降钙素原 C反应蛋白 脑功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]