ALV-J感染鸡骨髓细胞瘤中差异基因编码蛋白的互作网络分析  

Analysis of the interaction network between proteins coded by differentially expressed genes in myelocytoma of chickens infected by avian leukosis virus subgroup J

作　　者：杭柏林[1] 李杰[2] 张慧辉[1] 王倩倩[1] 徐彦召[1] 胡建和[1] 

机构地区：[1]河南科技学院,河南新乡453003 [2]新乡市畜产品质量监测检验中心,河南新乡453003

出　　处：《河南科技学院学报（自然科学版）》2016年第3期39-42,共4页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：河南科技学院大学生创新训练计划项目(2013CX047);河南科技学院高层次人才启动项目(2014020)

摘　　要：禽白血病病毒感染后可以引起宿主发生肿瘤.研究肿瘤组织中差异表达基因编码蛋白的相互作用,对理解禽白血病病毒的致病机制具有重要意义.基于文献中J亚群禽白血病病毒感染鸡骨髓瘤组织中差异表达基因编码蛋白进行了网络互作在线分析.结果表明:差异表达基因编码蛋白之间存在着复杂的相互作用,其中SRC网络、FYN网络、MYC网络和ERBB4网络对J亚群禽白血病病毒的致瘤机制可能具有重要作用.Avian leukosis virus can cause tumors in infected host.Research on interaction of proteins coded by differentially expressed genes in tumors is important for understanding the pathogenic mechanism of avian leukosis virus.Interaction network of proteins coded by differentially expressed genes in myelocytoma of chickens caused by avian leukosis virus subgroup J from references was analyzed with tools on line.The results showed that proteins coded by differentially expressed genes have comprehensive interaction network.The SRC network,FYN network,MYC network and ERBB4 network in interaction network may play important roles for the pathogenic mechanism of avian leukosis virus subgroup J.

关 键 词：J亚群禽白血病病毒 致瘤机制 差异基因编码蛋白 互作网络 

分 类 号：S852.65[农业科学—基础兽医学]