鼻腔和鼻窦鳞状细胞癌细胞中PRL-3及VEGF表达的临床意义  

The clinical significance of PRL-3,VEGF expression in sinonasal squamous cell carcinoma

作　　者：陆鸿略[1] 张淑君[1] 尹桂茹[1] 米洋[1] 康菲[2] 

机构地区：[1]承德医学院附属医院耳鼻咽喉科,河北承德0670002 [2]承德医学院附属医院体检科

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第13期1021-1024,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：承德市科学技术研究与发展计划项目(No:201601A047)

摘　　要：目的:探讨促肝细胞再生磷酸酶-3(PRL-3)和血管内皮生长因子(VEGF)在鼻腔、鼻窦鳞状细胞癌(SNSCC)中表达的临床意义。方法:采用免疫组织化学及RT-PCR方法检测62例SNSCC组织(SNSCC组)、30例鼻息肉组织(NP组)以及25例正常鼻腔黏膜(NM组)中PRL-3和VEGF的表达情况。结果:1SNSCC组中PRL-3和VEGF的表达明显高于NP组及NM组,差异有统计学意义(P<0.05);2SNSCC组中PRL-3和VEGF的表达情况在不同性别、年龄患者中无明显差别(P>0.05),而随着TNM分期的增高、分化程度的降低及伴淋巴结转移,PRL-3和VEGF的表达明显增高(P<0.05);3在SNSCC组中PRL-3以及VEGF的表达呈正相关(r=0.468,P<0.05)。结论:PRL-3及VEGF在SNSCC的增殖与分化调控中可能起到了重要作用,PRL-3和VEGF的高表达可反映SNSCC细胞的增殖活性,二者可能在肿瘤的侵袭转移过程中起到了协同促进作用。Objective：To analyze the clinical significance of phosphatase of regenerating liver-3（PRL-3）and vascular endothelial growth factor（VEGF）expression in sinonasal squamous cell carcinomas.Method：We use immunohistochemical analysis and RT-PCR to detecte the expression of PRL-3and VEGF protein in 62 cases of sinonasal squamous carcinoma tissues（SNSCC）,30 cases of nasal polyps（NP）,and 25 cases of normal nasal mucosa（NM）.Result：1The expression of PRL-3and VEGF in sinonasal squamous cell carcinoma tissues were statistically higher than in nasal polyps and normal nasal mucosa tissues（P〈0.05）.2The expression of PRL-3and VEGF were not correlated with patient＇s age or gender（P〉0.05）.But the High expression of PRL-3and VEGF in SNSCC was significantly related with advanced,lower tumor differentiation and lymph node metastasis（P〈0.05）.3The expression of PRL-3and VEGF was positively correlated in sinonasal squamous cell carcinomas.Conclusion：The expression of PRL-3and VEGF in SNSCC may involve in the regulation of tumor growth and differentiation.The expressing intensity may reflect the proliferation activity of sinonasal squamous cell carcinoma cell.PRL-3and VEGF may promote the tumor metastasis in a synergistic manner.

关 键 词：鳞状细胞癌 促肝细胞再生磷酸酶-3 血管内皮生长因子 

分 类 号：R739.6[医药卫生—肿瘤]