微小RNA-22在食管癌中的表达及临床意义  

The expression and clinical significance of micro RNA-22 in esophageal cancer

作　　者：胡立华[1] 陈鹏[1] 常英娟[1] 张鉴颖[1] 张继晔[1] 刘东杰[1] 

机构地区：[1]黑龙江省医院消化内科,黑龙江哈尔滨150036

出　　处：《中国现代医生》2016年第16期21-23,共3页China Modern Doctor

基　　金：黑龙江省卫生计生委科研课题(2014-129)

摘　　要：目的探讨微小RNA-22(mi RNA-22)在食管癌组织中的表达及与食管癌临床病理特征间的关系。方法采用实时定量PCR(real-time PCR,RT-PCR)法检测48例食管癌及癌旁组织中mi RNA-22的表达水平,分析mi RNA-22表达水平与食管癌患者临床病理特征之间的关系。结果食管癌组织中mi RNA-22相对表达量明显低于相应正常癌旁组织(3.51±1.05 vs 11.23±2.95),差异有统计学意义(P<0.05)。mi RNA-22低表达与肿瘤TNM分期及有无淋巴结转移密切相关,差异有统计学意义(P<0.05);而与性别、年龄、分化程度无明显相关性(P>0.05)。结论 mi RNA-22在食管癌组织中的表达下调与食管癌的临床病理特征密切相关。Objective To investigate the expression of miRNA-22 in esophageal cancer tissues and the relationship with the clinical pathologic features. Methods Real-time PCR was used to detect the miRNA-22 expressions among 48 cases of esophageal cancer tissues and matched adjacent tissues.The expression of miRNA-22 and clinic pathological features were analyzed. Results The esophageal cancer tissues showed aberrant down regulation of miRNA-22 com- pared with the adjacent non-tumor tissues （3.51±1.05 vs 11.23±2.95, P〈0.05）.Lower miRNA-22 level was strongly as- sociated with TNM stage and lymph node metastasis （P〈0.05）. The correlation statistical analysis result indicated that there was no significant difference in sex, age and differentiation grade （P〉0.05）. Conclusion The lower expression of miRNA-22 in esophageal cancer tissues is associated with clinic pathological features.

关 键 词：微小核糖核酸 食管癌 微小核糖核酸-22 实时定量PCR 

分 类 号：R735.1[医药卫生—肿瘤]