两种材料复合用于犬前牙拔牙位点保存的实验研究  

An experimental study of two materials used for the saving of the dog tooth extraction sites

作　　者：康立勋[1] 高艳宇[1] 

机构地区：[1]黑龙江省医院口腔种植中心,黑龙江哈尔滨150036

出　　处：《中国现代医生》2016年第17期25-27,34,共4页China Modern Doctor

基　　金：黑龙江省卫生计生委科研课题(2014-151)

摘　　要：目的探讨前牙拔牙位点即刻保存中重组合异种骨(reconstituted bone xenograft,RBX)与羟基磷灰石生物陶瓷复合物的作用。方法比格犬共6只,随机分为A、B、C组,每组各2只。所有动物拔除上颌全部第二切牙后,三组采用不同的实验方法,A组应用RBX与羟基磷灰石生物陶瓷复合物,B组仅应用羟基磷灰石生物陶瓷,C组为对照组,术后4周每组各处死1只犬,12周每组再处死1只犬,观察大体标本、形态学测量以及CT检查评价拔牙窝愈合情况。结果三组犬4、12周时唇舌侧牙槽嵴宽度差值比较差异均有统计学意义(P<0.05),A组差值最小;4周与12周时拔牙窝唇侧骨吸收程度A组阻止牙槽骨吸收效果最好,B组次之,C组最差;12周时A组唇侧牙槽嵴高度差值比较优于B组和C组(P<0.05);术后4周与12周CT值与术前CT值之差A组均高于B组和C组(P<0.05)。结论 RBX与羟基磷灰石生物陶瓷复合物联合应用,可减缓牙槽嵴吸收,促进新生骨形成,具有保存拔牙位点的作用,可作为良好的新型复合骨移植材料。Objective To discuss the function of RBX （reconstituted bone xenografi） and hydroxyapatite bioceramics complexes in the instant preservation of anterior extraction sockets. Methods Six beagle dogs were divided into group A, group B and group C, with 2 dogs in each group. After the extraction of both maxillary incisors, group A was immediately implanted RBX/hydroxyapatite bioceramics complexes, group B was implanted coralline hydroxyapatite, and group C was blank control. One dog from each group was sacrificed 4 weeks later and the other dog was sacrificed 12 weeks later to prepare tissue samples. The healing of extraction soket was evaluated by gross observation, morphological measurements and photographs of cone beam CT. Results There were significant differences in the labial-lingual alveolar ridge width difference among these three groups both 4 and 12 weeks later（P〈0.05）, and the smallest difference of labial-lingual width was in group A. In 4 and 12 weeks, the re-absorption in extraction area bone was the best in group A, followed by group B, and was the worst in group C. The labial alveolar bone height difference was better in group A than that in group B and group C in 12 weeks（P〈0.05）. The difference between postoperative cone beam CT value and preoperative cone beam CT value was higher in group A than that in group B and group C in 4 and 12 weeks （P〈0.05）. Conclusion RBX/hydroxyapatite bioceramics complex can be used as a new material in the field of bone graft which can slow the absorption of alveolar ridge, promote new bone formation, and save the tooth extraction sites.

关 键 词：重组合异种骨 羟基磷灰石生物陶瓷 位点保存 犬 

分 类 号：R783[医药卫生—口腔医学]