外泌体:乳腺癌精确诊疗的新热点  

Exosome: new hotspot in precision diagnosis and treatment of breast cancer

作　　者：盛湲[1] 李恒宇[1] 

机构地区：[1]第二军医大学附属长海医院乳腺外科,上海200433

出　　处：《中华乳腺病杂志（电子版）》2016年第3期133-136,共4页Chinese Journal of Breast Disease(Electronic Edition)

摘　　要：精准医学概念已被广泛认可,但如何实现更为精准的诊疗,仍有漫长的路要探索。继高通量测序、液态活组织检查、单细胞分析之后,外泌体已逐渐成为肿瘤研究的新热点。外泌体是循环囊泡的一种,也是细胞间通讯的重要介质之一,其本身具有稳定、可捕获、有生物活性、实时检测等特征。外泌体内携带的生物活性分子,参与肿瘤微环境中肿瘤细胞之间、肿瘤细胞与基质细胞之间的通讯,影响肿瘤发生、生长、侵袭和转移。本文通过分析外泌体在肿瘤早期发展、转移和耐药等过程中的作用,阐明其作为诊断标志物的优势与不足;通过分析其发挥生物学作用的方式以及与基因治疗经典传递方法相比较,来探讨其作为治疗载体的可行性。The concept of precision medicine has been widely accepted, but there is a long way to go before accurate diagnosis and treatment are achieved. Following the high-throughput sequencing, liquid biopsy and single cell technology, exosome has gradually become a new focus of cancer research. Exosomes are cell- derived vesicles and important intercellular communication mediators. They are stable and biologically active, meanwhile they could be captured and detected in real time. The bioactive molecules, which exosomes carry, are involved in the communication among tumor cells, between tumor cells and stromal cells in the tumor microenvironment, affecting tumorigenesis, tumor growth, invasion and metastasis. In this paper, we analyzed the role of exosomes in early stage development, metastasis and drug resistance of tumor, clarified its advantages and disadvantages as a diagnostic marker, investigated its biological function and explored its potential as a biological therapy compared with classical gene therapy

关 键 词：外泌体 乳腺肿瘤 精准医学 

分 类 号：R737.9[医药卫生—肿瘤]