汉族人群CNOT6基因多态性与胃癌易感性的关系  

Association study between genetic polymorphism in CNOT6 and risk of gastric cancer

作　　者：熊芳[1] 

机构地区：[1]首都医科大学附属北京佑安医院肝病与肿瘤生物治疗科,北京100069

出　　处：《临床荟萃》2016年第7期741-744,共4页Clinical Focus

摘　　要：目的探讨汉族人群中CNOT6基因3＇UTR区＋3908C〉T多态与胃癌易感性的关系。方法本病例对照研究人群为年龄和性别匹配的960例经手术病理证实的胃癌患者和972例对照健康者。采用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）分析个体CNOT6基因3＇UTR区＋3908C〉T多态的基因型。以比值比（odds ratio,OR）及其95%可信区间（confidence interval,CI）表示相对危险度。以logistic回归模型计算各基因型的OR及其95%CI。结果对于rs10069多态,TT/CT基因型携带者患胃癌的风险比CC基因型携带者显著降低（OR=0.74;95%CI=0.60~0.93）,在〈56岁患者中关联更显著。并且,CC基因型和幽门螺杆菌感染对胃癌发病风险存在累积作用（OR=2.32;95%CI=1.41~3.82）。结论 CNOT6基因＋3908C〉T多态与胃癌易感性相关。Objective To explore the association between the 3＇UTR＋3908 C〉T polymorphism of CNOT6 and susceptibility to gastric cancer in Han population. Methods The case-control study consisted of 960 patients with histopathologically verified primary gastric adenocarcinoma and age- and sex-matched healthy 972 controls in Chinese Han. The genotypes were determined by polymerase chain reaction-based restriction fragment length polymorphism （PCR-RFLP）. The associations between genotype and risk of developing gastric cancer were estimated by calculating the odds ratio （OR） and the 95% confidence interval （95% CI） with logistic regression models. Results For rs10069, subjects with TT/CT genotype had a decreased risk for developing gastric cancer compared with CC genotype（ OR = 0.74; 95% CI = 0. 60-0. 93 ）. The association was more pronounced among individuals with 〈 56 years of age. Moreover, a multiplicative joint effect between the CNOT6 SNP and Helicobacter pylori infection that intensified the risk was observed （ OR for the presence of both CC genotype and H. pylori infection=2.32;95%CI =1.41-3.82）. No significant association was observed between the polymorphism and stage and grade of the cancer. Conclusion The ＋3908 C〉T polymorphism of CNOT6 is associated with susceptibility to gastric cancer.

关 键 词：胃肿瘤 多态性 单核苷酸 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]