子宫内膜异位症与特定类型卵巢癌风险的相关性  

Correlation between endometriosis and the risk of a specific type of ovarian cancer

作　　者：赵静 谢冰松 郭端英 边亚芹[4] 吕世一[4] 

机构地区：[1]深圳市龙华人民医院花园新村门诊部妇科,广东深圳518109 [2]深圳市龙华人民医院花园新村门诊部全科,广东深圳518109 [3]深圳市龙岗人民医院妇科,广东深圳518116 [4]深圳市龙岗中心医院妇产科,广东深圳518116

出　　处：《中华实用诊断与治疗杂志》2016年第7期693-694,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨子宫内膜异位症(endometriosis,EM)与特定类型卵巢癌风险的相关性。方法单纯EM患者123例为单纯组,卵巢癌未合并EM患者69例为未合并组,卵巢癌合并EM患者9例为合并组。检测各组血清人附睾蛋白4(human epididymis protein 4,HE4)、糖链抗原125(carbohydrate antigen 125,CA125)水平,计算ROMA风险指数,并对卵巢癌患者病理分期、类型进行分析。结果合并组CA125[(389.91±13.79)u/mL]、HE4[(318.64±30.17)pmol/L]、ROMA指数[(90.48±7.13)%]高于未合并组[(367.94±12.94)u/mL、(220.67±28.47)pmol/L、(57.81±6.55)%]和单纯组[(30.72±9.07)u/mL、(68.91±15.49)pmol/L、(23.07±2.01)%],未合并组CA125、HE4、ROMA指数高于单纯组,组间比较差异均有统计学意义(P<0.05);未合并组患者病理分期多为Ⅰ期,以浆液性腺癌为主,合并组多为Ⅲ期,病理类型主要为透明细胞癌和子宫内膜样腺癌,2组病理分期、类型比较差异均有统计学意义(P<0.05)。结论EM有发生卵巢癌的风险,且与透明细胞癌和子宫内膜样腺癌发生有一定相关性,多数患者病理分化程度较低。Objective To investigate the relationship between endometriosis （EM） and the risk of a certain type of ovarian cancer. Methods The serum levels of human epididymis protein 4 （HE4） and carbohydrate antigen 125 （CA125） were detected in 123 patients with simple EM （EM group）, 69 ovarian cancer patients with no EM （ovarian cancer group） and 9 ovarian cancer patients with EM （combined group）. The ROMA risk index was calculated and the pathological staging and typing were analyzed in the patients with ovarian cancer. Results The levels of CA125, HE4 and ROMA index were significantly higher in combined group （（389. 91 ± 13. 79） u/mL, （318. 64± 30. 17） pmol/L, （90. 48± 7.13）%） than those in ovarian cancer group （（367.94±12.94） u/mL, （12.94±28.47） pmol/L, （57.81±6.55）%） and EM group （（30.72±9.07） u/mL, （9.07±15.49） pmol/L, （23.07±2.01） %）, and in ovarian cancer group than those in EM group （P〈0.05）. The pathological staging was mostly stage I in serous adenocarcinoma type in ovarian cancer group, and was stage Ⅲ in clear cell carcinoma type in combination group, showing significant differences between two groups （P〈0.05）. Conclusion EM is a risk factor for ovarian cancer, and is correlated with clear cell carcinoma and endometrial adenocarcinoma with poor differentiation.

关 键 词：子宫内膜异位症 卵巢癌 风险 

分 类 号：R737.31[医药卫生—肿瘤] R711.71[医药卫生—临床医学]