早期非小细胞肺癌经电视胸腔镜和开胸手术治疗疗效的Meta分析  

Meta Analysis on the Efficacy of Video-assisted Thoracoscpic Surgery(VATS) and Thoracotomy Surgery for Non-small Cell Lung Cancer Early Stage

作　　者：徐月亮[1] 王孝彬[1] 韩勇[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710000

出　　处：《肿瘤学杂志》2016年第7期583-588,共6页Journal of Chinese Oncology

摘　　要：[目的]评价电视胸腔镜手术(VATS)与开胸手术治疗早期非小细胞肺癌的近期疗效,以便为手术治疗决策提供依据。[方法]通过检索Pub Med、Embase、The Cochrane Library、中国生物医学文献数据库(CBM)和中国期刊网全文数据库(CNKI)等数据库,收集VATS与开胸手术治疗早期非小细胞肺癌近期疗效的随机对照试验(RCT),提取资料和评估方法学质量,采用Cochrane协作网Rev Man5.3软件进行Meta分析。[结果]共有8篇文献纳入研究,共计1358例患者。Meta分析结果显示:与传统开胸手术治疗相比较,VATS可减少胸腔引流量,并降低术后总的并发症发生率,缩短术后住院时间;但手术时间、淋巴结清扫数目、术中出血量、术后胸管留置时间等相当。[结论]现有的临床资料显示:与开胸手术相比,VATS是治疗早期非小细胞肺癌更好的选择,可以作为早期非小细胞肺癌的常规治疗手段。[Purpose] To evaluate the efficacy of video-assisted thoracoscpic surgery（VATS） and thoracotomy surgery for non-small cell lung cancer（NSCLC） early stage,and to provide evidence for the treatment decision. [Methods] The randomized controlled trials（RCT） about the efficacy of VATS and thoracotomy surgery for early stage NSCLC were searched on Pub Med,Embase,The Cochrane Library,Chinese Biomedical Literature Database（CBM） and China Journal Full-text Database（CNKI）. By extracting data and assessing methodological quality,Meta analysis was conducted by the Cochrane Collaboration Rev Man 5.3 software. [Results] Eight articles and 1358 patients were included. Meta analysis indicated that,compared with the traditional thoracotomy surgery,VATS reduced chest drainage,and reduced overall postoperative complication rate,decreased postoperative hospital stay;and had the similar efficacy about the operation time,the number of lymph node dissection,blood loss,postoperative chest tube indwelling time. [Conclusion]The limited clinical trials show there is some evidence supporting the use of VATS,and VATS might be a good alternative to traditional open lobectomy.

关 键 词：电视胸腔镜手术 开胸手术 非小细胞肺癌 META分析 

分 类 号：R734.2[医药卫生—肿瘤]