不同病理类型及分级胶质瘤细胞IDH1基因突变临床研究  

Research of different pathological types and levels of glioma cells IDH1 gene mutations in clinical

作　　者：罗秀萍[1] 陈茂君[1] 杨前美[1] 方丹[1] 彭洪春[1] 

机构地区：[1]四川大学华西医院神经外科,成都610041

出　　处：《陕西医学杂志》2016年第7期912-914,共3页Shaanxi Medical Journal

摘　　要：目的：研究不同病理类型及分级胶质瘤细胞IDH1基因突变情况。方法：收集胶质瘤患者175例的临床标本,检测并对比各类胶质瘤细胞的IDH1基因突变、WHO分级情况,分析IDH1基因突变与WHO分级及年龄的相关性。结果：175例胶质瘤标本中,共检出90例IDH1基因突变,总突变率51.43%。同时,弥漫型及间变性星形细胞瘤、继发性GBM、少突胶质瘤、少突星形细胞瘤的突变率均较野生型非突变率更高,差异有统计学意义。WHO分级为I级3.43%,Ⅱ级32.57%,Ⅲ级34.29%,Ⅳ级29.71%。IDH1基因突变型的年龄普遍较野生型更小,在弥漫型星形细胞瘤、继发性GBM及少突星形细胞瘤的突变型年龄显著低于野生型,差异有统计学意义。根据Pearson法分析相关性可知,IDH1基因突变与WHO分级呈正相关（r=0.619,P=0.023）,与年龄呈负相关（r=-0.784,P=0.000）。结论：IDH1基因突变在胶质瘤中具有较高的发生率,尤其是WHO分级Ⅱ~Ⅲ级及年龄较低者中,其对胶质瘤的形成及发展具有重要作用。Objective：To study the different pathological types and levels of glioma cells IDH1 gene mutations in clinical situations.Methods：175cases of patients with glioma clinical specimens were studied.Detection and compared all kinds of glioma cells IDH1 gene mutations,the WHO classification,patients＇ age,IDH1 gene mutations and the WHO classification were analyzed and the correlation of age.Results：in the 175 cases of gliomas specimens,90 cases were detected IDH1 gene mutation,the total mutation rate was 51.43%.At the same time,diffuse and anaplastic astrocytoma,less secondary GBM,tu glioma,（degeneration）mutation rate of astrocytoma were less than wild type of mutation rate is higher,the difference was statistically significant.The WHO classification forilevel,3.43% Ⅱlevel,32.57% Ⅲlevel,34.29% 29.71% Ⅳlevel.In all kinds of pathological types of glioma cells,IDH1 gene mutations age than the wild type was more common small,diffuse type（anaplastic）astrocytoma,and secondary GBM（anaplastic）oligoastrocytomas mutant tumor cells significantly younger than the wild type,the difference was statistically significant.Correlation analysis shows that,IDH1 gene mutation and WHO classification was based on pearson method positively correlated（r=0.619,P =0.023）,was negatively correlated with age（r=-0.784,P = 0.000）.Conclusion：IDH1gene mutation has a high incidence of gliomas,especially WHO grade Ⅱ ~ Ⅲgrade and lower the age of its formation and development of glioma has an important role.

关 键 词：神经胶质瘤/病理学 异柠檬酸脱氢酶 突变 

分 类 号：R651.1[医药卫生—外科学]