4种基因与视网膜色素变性危险因素交互作用分析  

Analysis on the interaction of 4 genes and retinitis pigmentosa risk factors

作　　者：董玉萍[1] 王磊峰[1] 李军[2] 郭志强[2] 董秋艳[1] 朱素芳[1] 李晓娟[1] 麻宁[2] 

机构地区：[1]武警北京总队第二医院眼科,北京100037 [2]武警北京总队第二医院检验科,北京100037

出　　处：《武警后勤学院学报（医学版）》2016年第6期450-453,468,共5页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】探讨SAG、TULP1、RDS、PRPF31基因与视网膜色素变性交互作用的关系,为视网膜色素变性的病因学研究、预防与延缓发展提供理论依据。【方法】通过4种易感基因进行筛查确定的5个等位基因,应用单纯病例组Logistic回归设计,分析4种基因与视网膜色素变性危险因素的交互作用。【结果】SAG基因rs1046974和PRPF31基因rs460824与食用鱼类食物存在交互作用(P=0.020,P=0.017),TULP1基因rs2064318和rs9380516及RDS基因rs434102与近亲结婚史、家族遗传史、吸烟饮酒、其它富含维生素A食物、精神状态均不存在统计学意义的交互作用(P>0.05)。【结论】SAG基因rs1046972、PRPF31基因rs460824与食用鱼类食物存在有统计学意义的交互作用(P<0.05)。【Objective】To explore the interactional relationship between the genes of SAG, TULP1, RDS and PRPF31 and retinitis pigmentosa, and provide a theoretical basis for etiology, prevention and development delay of retinitis pigmentosa.【Methods】Five alleles were identified by screening the 4 predisposing genes. Then interactions between the 4 genes and retinitis pigmentosa risk factors were analyzed via logistic regression for groups of case-only study.【Results】SAG gene rs1046974 and PRPF31 gene rs460824 had positive interactions with edible fish products（P=0.020, P=0.017）; TULP1 gene rs2064318 and rs9380516 and RDS gene rs434102 had no statistically significant interactions with history of consanguineous marriage, family history of inheritance, smoking, drinking, other foods rich in vitamin A and mental state（P0.05）.【Conclusions】There is a statistical interaction between SAG gene rs1046972 and PRPF31 gene rs460824 and edible fishes.

关 键 词：SAG基因 TULP1基因 RDS基因 PRPF31基因 交互作用 视网膜色素变性危险因素 

分 类 号：R774[医药卫生—眼科]