SLC1A1基因rs3087879位点多态性与强迫症的关系  

SLC1A1 GENE rs3087879 POLYMORPHISM AND ITS ASSOCIATION WITH OBSESSIVE-COMPULSIVE DISORDER

作　　者：丛金芝 张心华[1] 

机构地区：[1]青岛大学医学院医学心理学与精神病学教研室,山东青岛266003

出　　处：《青岛大学医学院学报》2016年第3期345-347,351,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨中国汉族人群谷氨酸转运体(SLC1A1)基因rs3087879位点单核苷酸多态性(SNP)与强迫症(OCD)的关系。方法采用聚合酶链式反应与限制性片段长度多态性(PCR-RFLP)技术,测定438例OCD病人和467例健康对照者SLC1A1基因rs3087879位点的基因型,分析该位点基因型频率、等位基因频率分布与OCD的关联性。结果 SLC1A1基因rs3087879位点共检出C/C、C/G、G/G等3种基因型,两组该位点基因型频率、等位基因频率分布比较,差异无显著性(P>0.05);按性别、发病年龄分层后,各组间在该位点上的基因型频率、等位基因频率分布差异均无显著性(P>0.05)。结论在中国汉族人群中,SLC1A1基因rs3087879位点SNP可能与OCD发病无关联性。Objective To explore the correlation between glutamate transporter gene solute carrier family 1 member 1（SLC1A1）and obsessive-compulsive disorder（OCD）in Chinese Han population. Methods Employing polymerase chain reaction and restriction fragment length polymorphism（PCR-RFLP）technique,the SLC1A1 gene of 438 OCD patients and 467 healthy controls was detected.The association of the genotype and allele frequency distribution with OCD was analyzed. Results Three genotypes-C/C,C/G,and G/G-of SLC1A1 gene rs3087879were detected.A comparison between the OCD group and the control group showed the differences were not significant in regard to the frequency distribution of genotype and allele at rs3087879（P0.05）.After stratification by sex and age of onset,no significant differences in distribution of genotype frequency and allele frequency on the site between each group were noted（P〉0.05）. Conclusion In Chinese Han population,single nucleotide polymorphism rs3087879 in SLC1A1gene may not be associated with the occurrence of obsessive-compulsive disorder.

关 键 词：强迫性人格障碍 谷氨酸转运体 多态性 单核苷酸 

分 类 号：R749.7[医药卫生—神经病学与精神病学]