改良DCF分周方案与XELOX方案治疗晚期胃癌疗效的比较  

A Clinical Comparison of Modified DCF Weekly Regimen and the XELOX Regimen in the Treatment of Advanced Gastric Cancer

作　　者：吴志伟[1] 于立江[1] 陆网坤[1] 陈凯[2] 蔡俊[1] 马德[1] 

机构地区：[1]江苏省靖江市人民医院肿瘤科,靖江214500 [2]苏州大学附属第一医院,苏州215006

出　　处：《中国肿瘤临床与康复》2016年第7期803-805,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨改良多西紫杉醇+顺铂+氟尿嘧啶(DCF)分周方案与卡培他滨+奥沙利铂(XELOX)方案治疗晚期胃癌的临床疗效。方法回顾性分析2009年6月至2015年6月间靖江市人民医院肿瘤科收治的98例晚期胃癌患者的临床资料,按治疗方法分为观察组和对照组,每组49例。观察组患者采用改良DCF分周方案治疗,对照组患者采用XELOX方案治疗,比较两组患者治疗后近期疗效、不良反应及生存时间的差异。结果观察组患者近期治疗有效率、疾病进展时间和中位生存时间明显优于对照组(P<0.05)。两组间腹泻、肌肉关节痛、血小板减少和肝功能损害比较差异无统计学意义(P>0.05)。对照组患者手足综合征发生率高,观察组患者恶心呕吐、白细胞减少和脱发发生率较高,差异均有统计学意义(P<0.05)。结论改良DCF分周方案较XELOX方案治疗晚期胃癌的疗效显著,但其不良反应还有待进一步研究。Objective To investigate the clinical efficacy of modified docetaxel ＋ cis-platinum ＋ fluorouracil （DCF） weekly regimen and the xeloda ＋ oxaliplatin （XELOX） regimen in the treatment of advanced gastric cancer. Methods The clinical records of 98 patients with advanced gastric cancer in The People＇s Hospital of Jingjiang City from June 2009 to June 2015 were retrospectively analyzed and they were divided into observation group （n = 49, treated with modified DCF weekly regimen） and control group （n = 49, treated with XELOX regimen） according to treatment method, then the short-term efficacy, toxicity and survival time in two groups after treatment were compared. Results The short-term effective rate, time to progress （TTP）, and the median survival time in the observation group were significantly better than those in the control group （ P 〈 0. 05 ）. There was no significant difference between the two groups on the side effects of diarrhea, muscle and joint pain, thrombocytopenia and liver function damage （ P 〉 0. 05 ）, however, the incidence of hand foot syndrome was higher in control group, and the the incidence of nausea and vomiting, white blood cells decrease, hair loss in the observation group were higher, and the differences were statistically significant （P 〈 0. 05 ）. Conclusion Compared with XELOX regimen, the modified DCF weekly regimen has better clinical efficacy, but its toxicity need further study.

关 键 词：胃肿瘤 药物疗法 不良反应 治疗结果 

分 类 号：R735.2[医药卫生—肿瘤]